FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112262451> ?p ?o ?g. }

• W2112262451 endingPage "1145" @default.
• W2112262451 startingPage "1140" @default.
• W2112262451 abstract "In this study, we have investigated the contribution of cholinergic-mediated bronchoconstriction in the airway response provoked by inhaled prostaglandin (PG)D2, its metabolite 9 alpha, 11 beta-PGF2, and PGF2 alpha, which are generated during mast cell activation in vivo and are potent bronchoconstrictor agonists in humans. The effect of prior inhalation of 1 mg ipratropium bromide (IB) on the bronchoconstrictor response to inhaled methacholine (MCh), PGD2, 9 alpha, 11 beta-PGF2, and PGF2 alpha was determined in 7 allergic asthmatic subjects by measuring changes in SGaw, FEV1, and Vmax30. Methacholine, PGD2, and 9 alpha, 11 beta-PGF2 caused concentration-related bronchoconstriction with PGD2 and 9 alpha, 11 beta-PGF2 being between 45 and 112 times more potent than MCh (p less than 0.05), depending on the method used to measure airway caliber. Preinhalation of IB displaced the concentration response curves to MCh between 69- and 196-fold to the right, and this was significantly greater than that observed with PGD2 (12- to 23-fold, p less than 0.02) and 9 alpha, 11 beta-PGF2 (12- to 22-fold, p less than 0.02). Ipratropium bromide inhibited the bronchoconstriction achieved with the highest concentration of agonist by 73 to 91% with MCh, 46 to 79% with PGD2, and 32 to 38% with 9 alpha, 11 beta-PGF2. Ipratropium bromide did not affect the bronchoconstriction pattern to inhaled PGF2 alpha, irrespective of the nature of the response. We conclude that although PGD2 and 9 alpha, 11 beta-PGF2 are potent contractile agonists of human smooth muscle in vitro, bronchoconstriction observed with these mediators in vivo results from a combination of both direct and cholinergic-mediated mechanisms." @default.
• W2112262451 created "2016-06-24" @default.
• W2112262451 creator A5026544861 @default.
• W2112262451 creator A5030571912 @default.
• W2112262451 creator A5044369001 @default.
• W2112262451 creator A5089020623 @default.
• W2112262451 date "1987-11-01" @default.
• W2112262451 modified "2023-10-16" @default.
• W2112262451 title "Cholinergic-Mediated Bronchoconstriction Induced by Prostaglandin D₂, Its Initial Metabolite 9α, 11β-PGF₂, and PGF_2αin Asthma" @default.
• W2112262451 cites W1855264373 @default.
• W2112262451 cites W1990233721 @default.
• W2112262451 cites W2037540059 @default.
• W2112262451 cites W2055132439 @default.
• W2112262451 cites W2055470889 @default.
• W2112262451 cites W2086624575 @default.
• W2112262451 cites W2146049100 @default.
• W2112262451 cites W2146275388 @default.
• W2112262451 cites W2323764868 @default.
• W2112262451 doi "https://doi.org/10.1164/ajrccm/136.5.1140" @default.
• W2112262451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2960256" @default.
• W2112262451 hasPublicationYear "1987" @default.
• W2112262451 type Work @default.
• W2112262451 sameAs 2112262451 @default.
• W2112262451 citedByCount "42" @default.
• W2112262451 countsByYear W21122624512015 @default.
• W2112262451 countsByYear W21122624512016 @default.
• W2112262451 countsByYear W21122624512018 @default.
• W2112262451 countsByYear W21122624512022 @default.
• W2112262451 crossrefType "journal-article" @default.
• W2112262451 hasAuthorship W2112262451A5026544861 @default.
• W2112262451 hasAuthorship W2112262451A5030571912 @default.
• W2112262451 hasAuthorship W2112262451A5044369001 @default.
• W2112262451 hasAuthorship W2112262451A5089020623 @default.
• W2112262451 hasConcept C126322002 @default.
• W2112262451 hasConcept C134018914 @default.
• W2112262451 hasConcept C159110408 @default.
• W2112262451 hasConcept C170493617 @default.
• W2112262451 hasConcept C185592680 @default.
• W2112262451 hasConcept C199360897 @default.
• W2112262451 hasConcept C2775944032 @default.
• W2112262451 hasConcept C2776042228 @default.
• W2112262451 hasConcept C2776174256 @default.
• W2112262451 hasConcept C2776178081 @default.
• W2112262451 hasConcept C2776954882 @default.
• W2112262451 hasConcept C2777361909 @default.
• W2112262451 hasConcept C2777477808 @default.
• W2112262451 hasConcept C2777714996 @default.
• W2112262451 hasConcept C2778938600 @default.
• W2112262451 hasConcept C2780532441 @default.
• W2112262451 hasConcept C2780664492 @default.
• W2112262451 hasConcept C2780769369 @default.
• W2112262451 hasConcept C2781018748 @default.
• W2112262451 hasConcept C2781260171 @default.
• W2112262451 hasConcept C41008148 @default.
• W2112262451 hasConcept C42219234 @default.
• W2112262451 hasConcept C49453240 @default.
• W2112262451 hasConcept C64943373 @default.
• W2112262451 hasConcept C71924100 @default.
• W2112262451 hasConcept C98274493 @default.
• W2112262451 hasConceptScore W2112262451C126322002 @default.
• W2112262451 hasConceptScore W2112262451C134018914 @default.
• W2112262451 hasConceptScore W2112262451C159110408 @default.
• W2112262451 hasConceptScore W2112262451C170493617 @default.
• W2112262451 hasConceptScore W2112262451C185592680 @default.
• W2112262451 hasConceptScore W2112262451C199360897 @default.
• W2112262451 hasConceptScore W2112262451C2775944032 @default.
• W2112262451 hasConceptScore W2112262451C2776042228 @default.
• W2112262451 hasConceptScore W2112262451C2776174256 @default.
• W2112262451 hasConceptScore W2112262451C2776178081 @default.
• W2112262451 hasConceptScore W2112262451C2776954882 @default.
• W2112262451 hasConceptScore W2112262451C2777361909 @default.
• W2112262451 hasConceptScore W2112262451C2777477808 @default.
• W2112262451 hasConceptScore W2112262451C2777714996 @default.
• W2112262451 hasConceptScore W2112262451C2778938600 @default.
• W2112262451 hasConceptScore W2112262451C2780532441 @default.
• W2112262451 hasConceptScore W2112262451C2780664492 @default.
• W2112262451 hasConceptScore W2112262451C2780769369 @default.
• W2112262451 hasConceptScore W2112262451C2781018748 @default.
• W2112262451 hasConceptScore W2112262451C2781260171 @default.
• W2112262451 hasConceptScore W2112262451C41008148 @default.
• W2112262451 hasConceptScore W2112262451C42219234 @default.
• W2112262451 hasConceptScore W2112262451C49453240 @default.
• W2112262451 hasConceptScore W2112262451C64943373 @default.
• W2112262451 hasConceptScore W2112262451C71924100 @default.
• W2112262451 hasConceptScore W2112262451C98274493 @default.
• W2112262451 hasIssue "5" @default.
• W2112262451 hasLocation W21122624511 @default.
• W2112262451 hasLocation W21122624512 @default.
• W2112262451 hasOpenAccess W2112262451 @default.
• W2112262451 hasPrimaryLocation W21122624511 @default.
• W2112262451 hasRelatedWork W166776206 @default.
• W2112262451 hasRelatedWork W1985000856 @default.
• W2112262451 hasRelatedWork W1999499577 @default.
• W2112262451 hasRelatedWork W2066635153 @default.
• W2112262451 hasRelatedWork W2109469343 @default.
• W2112262451 hasRelatedWork W2111730179 @default.
• W2112262451 hasRelatedWork W2112262451 @default.
• W2112262451 hasRelatedWork W2153076417 @default.

• next