FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112276842> ?p ?o ?g. }

• W2112276842 endingPage "1457" @default.
• W2112276842 startingPage "1450" @default.
• W2112276842 abstract "Stomach carcinogenesis progresses stepwise from normal mucosa/superficial gastritis, atrophic gastritis (GA) to gastric cancer (GC). Host factors independent of or combined with Helicobacter pylori infection may modulate the carcinogenesis process. In this two-stage study, we selected 24 putative functional tag single-nucleotide polymorphisms (tagSNPs) for six H.pylori -related host genes, MUC1 , toll-like receptor 4 ( TLR4 ), protein tyrosine phosphatase, non-receptor type 11 ( PTPN11 ), IL-1B , PGC and PGA3–5 , and analyzed their influence and interaction with H.pylori on the GA and GC risks. Using high-throughput genotyping, the 24 tagSNPs were preliminarily assessed in a screening population of 552 controls, 254 GA and 236 GC subjects; subsequently, five candidate tagSNPs for gastric diseases risk in the TLR4 , PGC and PTPN11 genes were re-evaluated in a larger population of 1276 controls, 907GA and 714 GC subjects. We observed that PGC rs6458238, PGC rs4711690 and PTPN11 rs12229892 were associated with susceptibilities to GA and/or GC. Moreover, rs4711690 and rs12229892 and H.pylori demonstrated significant interaction effects on GA risk. In gastric cancerous specimens, we observed significantly higher messenger RNA level in the subjects carrying the PGC rs6458238 GA genotype than that in subjects with the common GG genotype. These findings indicated that genetic variations of two crucial H.pylori -related host genes, H.pylori’ s mucosal effecter PGC gene and H.pylori’s cellular messenger PTPN11 gene, either dependent or independent of interaction with H.pylori , were associated with the risks of GC and/or GA that precede carcinoma. Functional studies and further independent large-scale studies especially in other ethnic populations are still needed to confirm our results." @default.
• W2112276842 created "2016-06-24" @default.
• W2112276842 creator A5009236084 @default.
• W2112276842 creator A5011540763 @default.
• W2112276842 creator A5040392788 @default.
• W2112276842 creator A5051181240 @default.
• W2112276842 creator A5060901085 @default.
• W2112276842 creator A5073070877 @default.
• W2112276842 creator A5079734726 @default.
• W2112276842 creator A5090177646 @default.
• W2112276842 date "2013-03-01" @default.
• W2112276842 modified "2023-10-12" @default.
• W2112276842 title "Helicobacter pylori-related host gene polymorphisms associated with susceptibility of gastric carcinogenesis: a two-stage case-control study in Chinese" @default.
• W2112276842 cites W1489033175 @default.
• W2112276842 cites W1536632015 @default.
• W2112276842 cites W1577033137 @default.
• W2112276842 cites W1969673534 @default.
• W2112276842 cites W1974592831 @default.
• W2112276842 cites W1975600230 @default.
• W2112276842 cites W1981762250 @default.
• W2112276842 cites W1988599811 @default.
• W2112276842 cites W1992945893 @default.
• W2112276842 cites W1996014846 @default.
• W2112276842 cites W1997652490 @default.
• W2112276842 cites W1998582997 @default.
• W2112276842 cites W2007117166 @default.
• W2112276842 cites W2012206062 @default.
• W2112276842 cites W2018019975 @default.
• W2112276842 cites W2018261052 @default.
• W2112276842 cites W2019893733 @default.
• W2112276842 cites W2021074342 @default.
• W2112276842 cites W2027520433 @default.
• W2112276842 cites W2035037423 @default.
• W2112276842 cites W2041189251 @default.
• W2112276842 cites W2045834167 @default.
• W2112276842 cites W2046706071 @default.
• W2112276842 cites W2051230054 @default.
• W2112276842 cites W2052246515 @default.
• W2112276842 cites W2052498400 @default.
• W2112276842 cites W2057340526 @default.
• W2112276842 cites W2059408713 @default.
• W2112276842 cites W2062503200 @default.
• W2112276842 cites W2066686193 @default.
• W2112276842 cites W2079130007 @default.
• W2112276842 cites W2083310102 @default.
• W2112276842 cites W2085707327 @default.
• W2112276842 cites W2088181514 @default.
• W2112276842 cites W2088335869 @default.
• W2112276842 cites W2103034675 @default.
• W2112276842 cites W2107277218 @default.
• W2112276842 cites W2125173799 @default.
• W2112276842 cites W2142782172 @default.
• W2112276842 cites W2145388460 @default.
• W2112276842 cites W2149385661 @default.
• W2112276842 cites W2153354382 @default.
• W2112276842 cites W2171535037 @default.
• W2112276842 cites W2948387191 @default.
• W2112276842 doi "https://doi.org/10.1093/carcin/bgt079" @default.
• W2112276842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23455381" @default.
• W2112276842 hasPublicationYear "2013" @default.
• W2112276842 type Work @default.
• W2112276842 sameAs 2112276842 @default.
• W2112276842 citedByCount "46" @default.
• W2112276842 countsByYear W21122768422013 @default.
• W2112276842 countsByYear W21122768422014 @default.
• W2112276842 countsByYear W21122768422015 @default.
• W2112276842 countsByYear W21122768422016 @default.
• W2112276842 countsByYear W21122768422017 @default.
• W2112276842 countsByYear W21122768422018 @default.
• W2112276842 countsByYear W21122768422019 @default.
• W2112276842 countsByYear W21122768422020 @default.
• W2112276842 countsByYear W21122768422021 @default.
• W2112276842 countsByYear W21122768422022 @default.
• W2112276842 countsByYear W21122768422023 @default.
• W2112276842 crossrefType "journal-article" @default.
• W2112276842 hasAuthorship W2112276842A5009236084 @default.
• W2112276842 hasAuthorship W2112276842A5011540763 @default.
• W2112276842 hasAuthorship W2112276842A5040392788 @default.
• W2112276842 hasAuthorship W2112276842A5051181240 @default.
• W2112276842 hasAuthorship W2112276842A5060901085 @default.
• W2112276842 hasAuthorship W2112276842A5073070877 @default.
• W2112276842 hasAuthorship W2112276842A5079734726 @default.
• W2112276842 hasAuthorship W2112276842A5090177646 @default.
• W2112276842 hasBestOaLocation W21122768421 @default.
• W2112276842 hasConcept C104317684 @default.
• W2112276842 hasConcept C121608353 @default.
• W2112276842 hasConcept C135763542 @default.
• W2112276842 hasConcept C153209595 @default.
• W2112276842 hasConcept C203014093 @default.
• W2112276842 hasConcept C2776409635 @default.
• W2112276842 hasConcept C2778204961 @default.
• W2112276842 hasConcept C2778677798 @default.
• W2112276842 hasConcept C2908647359 @default.
• W2112276842 hasConcept C54355233 @default.
• W2112276842 hasConcept C555283112 @default.
• W2112276842 hasConcept C60987743 @default.
• W2112276842 hasConcept C71924100 @default.
• W2112276842 hasConcept C86803240 @default.

• next