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• W2112286558 abstract "Breast cancer is the most common malignancy in the American female. It is estimated that more than 200,000 women will be diagnosed in the year 2004. With appropriate screening, most patients are detected at an early stage. And the local treatment options for these patients are either total mastectomy with or without reconstruction or breast conservation therapy (BCT). BCT consists of lumpectomy and axillary lymph node sampling followed by radiation therapy. There are six prospective phase 3 randomized studies in America and Europe with long follow-up (up to 20 years) showing equivalent local control and survival for the two treatment modalities. In appropriately selected patients with early-stage breast cancer, a number of randomized trials have found that BCT results in survival equivalent to that documented with mastectomy. 1–3 Despite these results, up to 50% of patients with early-stage breast cancer do not receive BCT. Additionally, it is estimated that 25% of women who receive a lumpectomy do not receive radiation therapy at all. 4 Further randomized trials have been conducted to determine if radiation therapy can be omitted after lumpectomy, but to date no subset of patients has been identified that should be treated with surgery alone. The current standard of care for BCT includes postlumpectomy whole breast radiation therapy. However, there are several contemporary publications indicating that the primary benefit of radiation therapy is a reduction in the risk of local tumor recurrence, with little effect on the incidence of recurrence away from the tumor bed. 5,6 During the past decade, this information has led researchers from single institutions and the Radiation Therapy Oncology Group to conduct prospective trials investigating 4- or 5-day breast brachytherapy as the radiation treatment regimen used in conjunction with lumpectomy. Brachytherapy, or internal radiation therapy, enables physicians to deliver a therapeutic dose of radiation to the tissue at highest risk for recurrence while minimizing exposure to the surrounding healthy tissue. Numerous clinical studies of both low-dose rate and high-dose rate brachytherapy for treatment of breast cancer have been conducted worldwide and demonstrate low local recurrence rates. 7–18 These recently reported results have generated increased interest in the practice of brachytherapy for treatment of breast cancer. Such treatment may enable physicians to offer the benefits of BCT to more patients." @default.
• W2112286558 created "2016-06-24" @default.
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• W2112286558 date "2004-12-01" @default.
• W2112286558 modified "2023-09-26" @default.
• W2112286558 title "Accelerated breast brachytherapy: an effective and convenient alternative for selected patients with early-stage breast cancer" @default.
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• W2112286558 doi "https://doi.org/10.3109/14733400400030216" @default.
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