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- W2112312001 abstract "The concentration of cholesterol in the low-density-lipoprotein (LDL) fraction of plasma is one of the major risk factors for coronary heart disease. Steady-state concentrations of LDL cholesterol in the plasma are determined primarily by the production rate and the rate of removal of LDL cholesterol from the circulation by receptor-dependent transport. The magnitude of these two processes is affected by the type of fatty acid in the diet. Saturated fatty acids with 14 and 16 carbon atoms suppress receptor-dependent LDL-cholesterol transport into the liver, increase the LDL-cholesterol production rate, and raise the plasma LDL-cholesterol concentration. The 9-cis18:1 fatty acid restores receptor activity, lowers the production rate, and decreases the plasma LDL-cholesterol concentration. In contrast with these fatty acids, the 18:0 and 9-trans18:1 fatty acids are biologically inactive and so do not change the circulating LDL-cholesterol concentration." @default.
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- W2112312001 title "Effect of long-chain fatty acids on low-density-lipoprotein-cholesterol metabolism" @default.
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- W2112312001 doi "https://doi.org/10.1093/ajcn/60.6.991s" @default.
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