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- W2112320300 endingPage "066003" @default.
- W2112320300 startingPage "066003" @default.
- W2112320300 abstract "Growing evidence suggests that critical cellular processes are profoundly influenced by the cross talk between extracellular nanomechanical forces and the material properties of the cellular microenvironment. Although many studies have examined either the effect of nanomechanical forces or the material properties of the microenvironment on biological processes, few have investigated the influence of both. Here, we performed simultaneous atomic force microscopy and traction force microscopy to demonstrate that muscle precursor cells (myoblasts) rapidly generate a significant increase in traction when stimulated with a local 10 nN force. Cells were cultured and nanomechanically stimulated on hydrogel substrates with controllable local elastic moduli varying from ~16-89 kPa, as confirmed with atomic force microscopy. Importantly, cellular traction dynamics in response to nanomechanical stimulation only occurred on substrates that were similar to the elasticity of working muscle tissue (~64-89 kPa) as opposed to substrates mimicking resting tissue (~16-51 kPa). The traction response was also transient, occurring within 30 s, and dissipating by 60 s, during constant nanomechanical stimulation. The observed biophysical dynamics are very much dependent on rho-kinase and myosin-II activity and likely contribute to the physiology of these cells. Our results demonstrate the fundamental ability of cells to integrate nanoscale information in the cellular microenvironment, such as nanomechanical forces and substrate mechanics, during the process of mechanotransduction." @default.
- W2112320300 created "2016-06-24" @default.
- W2112320300 creator A5033501255 @default.
- W2112320300 creator A5052205312 @default.
- W2112320300 date "2013-10-29" @default.
- W2112320300 modified "2023-10-07" @default.
- W2112320300 title "Cross talk between matrix elasticity and mechanical force regulates myoblast traction dynamics" @default.
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- W2112320300 cites W1965933207 @default.
- W2112320300 cites W1969964831 @default.
- W2112320300 cites W1976709402 @default.
- W2112320300 cites W1977815598 @default.
- W2112320300 cites W1983805504 @default.
- W2112320300 cites W1986093704 @default.
- W2112320300 cites W1987367101 @default.
- W2112320300 cites W1991237283 @default.
- W2112320300 cites W1993686201 @default.
- W2112320300 cites W1994695193 @default.
- W2112320300 cites W2000465700 @default.
- W2112320300 cites W2004871707 @default.
- W2112320300 cites W2006486639 @default.
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- W2112320300 cites W2024250498 @default.
- W2112320300 cites W2027093378 @default.
- W2112320300 cites W2030005835 @default.
- W2112320300 cites W2030600914 @default.
- W2112320300 cites W2030895815 @default.
- W2112320300 cites W2032334748 @default.
- W2112320300 cites W2032647105 @default.
- W2112320300 cites W2033975886 @default.
- W2112320300 cites W2035382078 @default.
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- W2112320300 cites W2074249457 @default.
- W2112320300 cites W2074626626 @default.
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- W2112320300 cites W2150338395 @default.
- W2112320300 cites W2153626442 @default.
- W2112320300 cites W2156865492 @default.
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- W2112320300 doi "https://doi.org/10.1088/1478-3975/10/6/066003" @default.
- W2112320300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24164970" @default.
- W2112320300 hasPublicationYear "2013" @default.
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