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• W2112323010 endingPage "846" @default.
• W2112323010 startingPage "833" @default.
• W2112323010 abstract "Hepatic ischemia/reperfusion (I/R) injury is a side effect of major liver surgery that often cannot be avoided. Prolonged periods of ischemia put a metabolic strain on hepatocytes and limit the tolerable ischemia and preservation times during liver resection and transplantation, respectively. In both surgical settings, temporarily lowering the metabolic demand of the organ by reducing organ temperature effectively counteracts the negative consequences of an ischemic insult. Despite its routine use, the application of liver cooling is predicated on an incomplete understanding of the underlying protective mechanisms, which has limited a uniform and widespread implementation of liver-cooling techniques. This review therefore addresses how hypothermia-induced hypometabolism modulates hepatocyte metabolism during ischemia and thereby reduces hepatic I/R injury. The mechanisms underlying hypothermia-mediated reduction in energy expenditure during ischemia and the attenuation of mitochondrial production of reactive oxygen species during early reperfusion are described. It is further addressed how hypothermia suppresses the sterile hepatic I/R immune response and preserves the metabolic functionality of hepatocytes. Lastly, a summary of the clinical status quo of the use of liver cooling for liver resection and transplantation is provided." @default.
• W2112323010 created "2016-06-24" @default.
• W2112323010 creator A5025706577 @default.
• W2112323010 creator A5037661266 @default.
• W2112323010 creator A5039369677 @default.
• W2112323010 creator A5052059898 @default.
• W2112323010 creator A5055483179 @default.
• W2112323010 creator A5078824354 @default.
• W2112323010 date "2015-01-01" @default.
• W2112323010 modified "2023-10-13" @default.
• W2112323010 title "Protective Mechanisms of Hypothermia in Liver Surgery and Transplantation" @default.
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