FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112323346> ?p ?o ?g. }

• W2112323346 endingPage "1257" @default.
• W2112323346 startingPage "1245" @default.
• W2112323346 abstract "Metabolic profiling of plasma nonesterified fatty acids discovered that palmitic acid (PA), a natural peroxisome proliferator-activated receptor γ (PPARγ) ligand, is a reliable type 2 diabetes biomarker. We investigated whether and how PA diabetic (d-PA) concentrations affected endothelial progenitor cell (EPC) and bone marrow-derived hematopoietic cell (BM-HC) biology. PA physiologic (n-PA) and d-PA concentrations were used. Proliferating cell nuclear antigen content and signal transducer and activator of transcription 5 (STAT5), PPARγ, cyclin D1, and p21(Waf) expression were evaluated. Small interfering RNA technology, gene reporter luciferase assay, electrophoretic mobility shift assay, chromatin immunoprecipitation assay, and coimmunoprecipitation were exploited. In vivo studies and migration assays were also performed. d-PA, unlike n-PA or physiological and diabetic oleic and stearic acid concentrations, impaired EPC migration and EPC/BM-HC proliferation through a PPARγ-mediated STAT5 transcription inhibition. This event did not prevent the formation of a STAT5/PPARγ transcriptional complex but was crucial for gene targeting, as p21(Waf) gene promoter, unlike cyclin D1, was the STAT5/PPARγ transcriptional target. Similar molecular events could be detected in EPCs isolated from type 2 diabetic patients. By expressing a constitutively activated STAT5 form, we demonstrated that STAT5 content is crucial for gene targeting and EPC fate. Finally, we also provide in vivo data that d-PA-mediated EPC dysfunction could be rescued by PPARγ blockade. These data provide first insights on how mechanistically d-PA drives EPC/BM-HC dysfunction in diabetes." @default.
• W2112323346 created "2016-06-24" @default.
• W2112323346 creator A5000476200 @default.
• W2112323346 creator A5001080878 @default.
• W2112323346 creator A5017097792 @default.
• W2112323346 creator A5041045830 @default.
• W2112323346 creator A5069367075 @default.
• W2112323346 creator A5084434161 @default.
• W2112323346 creator A5090995256 @default.
• W2112323346 date "2013-03-14" @default.
• W2112323346 modified "2023-10-07" @default.
• W2112323346 title "Increase of Palmitic Acid Concentration Impairs Endothelial Progenitor Cell and Bone Marrow–Derived Progenitor Cell Bioavailability" @default.
• W2112323346 cites W1839949933 @default.
• W2112323346 cites W1914988672 @default.
• W2112323346 cites W1917578864 @default.
• W2112323346 cites W1970622371 @default.
• W2112323346 cites W1972977323 @default.
• W2112323346 cites W1976791967 @default.
• W2112323346 cites W1978380407 @default.
• W2112323346 cites W1982054742 @default.
• W2112323346 cites W1986991023 @default.
• W2112323346 cites W1988320060 @default.
• W2112323346 cites W1989775577 @default.
• W2112323346 cites W1992291115 @default.
• W2112323346 cites W1995134855 @default.
• W2112323346 cites W1996717633 @default.
• W2112323346 cites W2003282728 @default.
• W2112323346 cites W2010438605 @default.
• W2112323346 cites W2016508852 @default.
• W2112323346 cites W2025814716 @default.
• W2112323346 cites W2032865993 @default.
• W2112323346 cites W2033204507 @default.
• W2112323346 cites W2034974668 @default.
• W2112323346 cites W2035481611 @default.
• W2112323346 cites W2051091267 @default.
• W2112323346 cites W2059345192 @default.
• W2112323346 cites W2062183137 @default.
• W2112323346 cites W2064715676 @default.
• W2112323346 cites W2066418725 @default.
• W2112323346 cites W2070367531 @default.
• W2112323346 cites W2072374199 @default.
• W2112323346 cites W2073171330 @default.
• W2112323346 cites W2077247213 @default.
• W2112323346 cites W2085126321 @default.
• W2112323346 cites W2098108405 @default.
• W2112323346 cites W2098888745 @default.
• W2112323346 cites W2101921820 @default.
• W2112323346 cites W2106991956 @default.
• W2112323346 cites W2124949523 @default.
• W2112323346 cites W2127872440 @default.
• W2112323346 cites W2136484483 @default.
• W2112323346 cites W2139002144 @default.
• W2112323346 cites W2147937205 @default.
• W2112323346 cites W2150174495 @default.
• W2112323346 cites W2167267751 @default.
• W2112323346 cites W2169224393 @default.
• W2112323346 cites W2315982688 @default.
• W2112323346 cites W2331369555 @default.
• W2112323346 doi "https://doi.org/10.2337/db12-0646" @default.
• W2112323346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3609587" @default.
• W2112323346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23223023" @default.
• W2112323346 hasPublicationYear "2013" @default.
• W2112323346 type Work @default.
• W2112323346 sameAs 2112323346 @default.
• W2112323346 citedByCount "40" @default.
• W2112323346 countsByYear W21123233462013 @default.
• W2112323346 countsByYear W21123233462014 @default.
• W2112323346 countsByYear W21123233462015 @default.
• W2112323346 countsByYear W21123233462016 @default.
• W2112323346 countsByYear W21123233462017 @default.
• W2112323346 countsByYear W21123233462018 @default.
• W2112323346 countsByYear W21123233462019 @default.
• W2112323346 countsByYear W21123233462020 @default.
• W2112323346 countsByYear W21123233462021 @default.
• W2112323346 countsByYear W21123233462022 @default.
• W2112323346 countsByYear W21123233462023 @default.
• W2112323346 crossrefType "journal-article" @default.
• W2112323346 hasAuthorship W2112323346A5000476200 @default.
• W2112323346 hasAuthorship W2112323346A5001080878 @default.
• W2112323346 hasAuthorship W2112323346A5017097792 @default.
• W2112323346 hasAuthorship W2112323346A5041045830 @default.
• W2112323346 hasAuthorship W2112323346A5069367075 @default.
• W2112323346 hasAuthorship W2112323346A5084434161 @default.
• W2112323346 hasAuthorship W2112323346A5090995256 @default.
• W2112323346 hasBestOaLocation W21123233461 @default.
• W2112323346 hasConcept C101762097 @default.
• W2112323346 hasConcept C104317684 @default.
• W2112323346 hasConcept C134320426 @default.
• W2112323346 hasConcept C14093617 @default.
• W2112323346 hasConcept C1491633281 @default.
• W2112323346 hasConcept C150194340 @default.
• W2112323346 hasConcept C153911025 @default.
• W2112323346 hasConcept C170493617 @default.
• W2112323346 hasConcept C185592680 @default.
• W2112323346 hasConcept C187345961 @default.
• W2112323346 hasConcept C199835354 @default.
• W2112323346 hasConcept C201750760 @default.
• W2112323346 hasConcept C28328180 @default.

• next