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- W2112340727 startingPage "e1000410" @default.
- W2112340727 abstract "Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas crossovers between repeated genes on non-homologous chromosomes can result in translocations. Using a genetic system that allows selection of daughter cells that contain the reciprocal products of mitotic crossing over, we mapped crossovers and gene conversion events at a resolution of about 4 kb in a 120-kb region of chromosome V of Saccharomyces cerevisiae. The gene conversion tracts associated with mitotic crossovers are much longer (averaging about 12 kb) than the conversion tracts associated with meiotic recombination and are non-randomly distributed along the chromosome. In addition, about 40% of the conversion events have patterns of marker segregation that are most simply explained as reflecting the repair of a chromosome that was broken in G1 of the cell cycle." @default.
- W2112340727 created "2016-06-24" @default.
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- W2112340727 creator A5078766444 @default.
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- W2112340727 date "2009-03-13" @default.
- W2112340727 modified "2023-09-27" @default.
- W2112340727 title "A Fine-Structure Map of Spontaneous Mitotic Crossovers in the Yeast Saccharomyces cerevisiae" @default.
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- W2112340727 doi "https://doi.org/10.1371/journal.pgen.1000410" @default.
- W2112340727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2646836" @default.
- W2112340727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19282969" @default.
- W2112340727 hasPublicationYear "2009" @default.
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