Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112363721> ?p ?o ?g. }
- W2112363721 endingPage "3994" @default.
- W2112363721 startingPage "3983" @default.
- W2112363721 abstract "Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of neurotrophic factor receptors. Approximately half of unmyelinated nociceptors express the NGF receptor TrkA, and half express the GDNF family ligand (GFL) receptor Ret. The function of NGF/TrkA signaling in the TrkA population of nociceptors has been extensively studied, and NGF/TrkA signaling is a well established mediator of pain. The GFLs are analgesic in models of neuropathic pain emphasizing the importance of understanding the physiological function of GFL/Ret signaling in nociceptors. However, perinatal lethality of Ret -null mice has precluded the study of the physiological role of GFL/Ret signaling in the survival, maintenance, and function of nociceptors in viable mice. We deleted Ret exclusively in nociceptors by crossing nociceptor-specific Na v 1.8 Cre and Ret conditional mice to produce Ret-Na v 1.8 conditional knock-out (CKO) mice. Loss of Ret exclusively in nociceptors results in a reduction in nociceptor number and size, indicating that Ret signaling is important for the survival and trophic support of these cells. Ret-Na v 1.8 CKO mice exhibit reduced epidermal innervation but normal central projections. In addition, Ret-Na v 1.8 CKO mice have increased sensitivity to cold and increased formalin-induced pain, demonstrating that Ret signaling modulates the function of nociceptors in vivo . Enhanced inflammation-induced pain may be mediated by decreased prostatic acid phosphatase (PAP), as PAP levels are markedly reduced in Ret-Na v 1.8 CKO mice. The results of this study identify the physiological role of endogenous Ret signaling in the survival and function of nociceptors." @default.
- W2112363721 created "2016-06-24" @default.
- W2112363721 creator A5004205875 @default.
- W2112363721 creator A5006363718 @default.
- W2112363721 creator A5027743516 @default.
- W2112363721 creator A5040885096 @default.
- W2112363721 creator A5044748002 @default.
- W2112363721 creator A5062336590 @default.
- W2112363721 creator A5070827775 @default.
- W2112363721 creator A5086652241 @default.
- W2112363721 creator A5089423258 @default.
- W2112363721 date "2010-03-17" @default.
- W2112363721 modified "2023-10-16" @default.
- W2112363721 title "RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors" @default.
- W2112363721 cites W1512880472 @default.
- W2112363721 cites W1523160166 @default.
- W2112363721 cites W1917144620 @default.
- W2112363721 cites W1933310320 @default.
- W2112363721 cites W1966917600 @default.
- W2112363721 cites W1971208141 @default.
- W2112363721 cites W1971935688 @default.
- W2112363721 cites W1976572747 @default.
- W2112363721 cites W1978100445 @default.
- W2112363721 cites W1981881657 @default.
- W2112363721 cites W1982095811 @default.
- W2112363721 cites W1985324043 @default.
- W2112363721 cites W1986235075 @default.
- W2112363721 cites W1987566228 @default.
- W2112363721 cites W1990578633 @default.
- W2112363721 cites W1990662335 @default.
- W2112363721 cites W1999370442 @default.
- W2112363721 cites W2000791321 @default.
- W2112363721 cites W2002620715 @default.
- W2112363721 cites W2008325064 @default.
- W2112363721 cites W2017240636 @default.
- W2112363721 cites W2034858091 @default.
- W2112363721 cites W2035210392 @default.
- W2112363721 cites W2040352709 @default.
- W2112363721 cites W2050369461 @default.
- W2112363721 cites W2050725524 @default.
- W2112363721 cites W2055945798 @default.
- W2112363721 cites W2061601658 @default.
- W2112363721 cites W2071595010 @default.
- W2112363721 cites W2073489542 @default.
- W2112363721 cites W2077483410 @default.
- W2112363721 cites W2080725562 @default.
- W2112363721 cites W2083107042 @default.
- W2112363721 cites W2089073273 @default.
- W2112363721 cites W2107277218 @default.
- W2112363721 cites W2121038814 @default.
- W2112363721 cites W2126229620 @default.
- W2112363721 cites W2137979524 @default.
- W2112363721 cites W2141005071 @default.
- W2112363721 cites W2142589109 @default.
- W2112363721 cites W2144168839 @default.
- W2112363721 cites W2145277005 @default.
- W2112363721 cites W2147753672 @default.
- W2112363721 cites W2156509935 @default.
- W2112363721 cites W2156733405 @default.
- W2112363721 cites W2162127443 @default.
- W2112363721 cites W2166265100 @default.
- W2112363721 cites W3198499435 @default.
- W2112363721 doi "https://doi.org/10.1523/jneurosci.5930-09.2010" @default.
- W2112363721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2850282" @default.
- W2112363721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20237269" @default.
- W2112363721 hasPublicationYear "2010" @default.
- W2112363721 type Work @default.
- W2112363721 sameAs 2112363721 @default.
- W2112363721 citedByCount "78" @default.
- W2112363721 countsByYear W21123637212012 @default.
- W2112363721 countsByYear W21123637212013 @default.
- W2112363721 countsByYear W21123637212014 @default.
- W2112363721 countsByYear W21123637212015 @default.
- W2112363721 countsByYear W21123637212016 @default.
- W2112363721 countsByYear W21123637212017 @default.
- W2112363721 countsByYear W21123637212018 @default.
- W2112363721 countsByYear W21123637212019 @default.
- W2112363721 countsByYear W21123637212020 @default.
- W2112363721 countsByYear W21123637212021 @default.
- W2112363721 countsByYear W21123637212022 @default.
- W2112363721 countsByYear W21123637212023 @default.
- W2112363721 crossrefType "journal-article" @default.
- W2112363721 hasAuthorship W2112363721A5004205875 @default.
- W2112363721 hasAuthorship W2112363721A5006363718 @default.
- W2112363721 hasAuthorship W2112363721A5027743516 @default.
- W2112363721 hasAuthorship W2112363721A5040885096 @default.
- W2112363721 hasAuthorship W2112363721A5044748002 @default.
- W2112363721 hasAuthorship W2112363721A5062336590 @default.
- W2112363721 hasAuthorship W2112363721A5070827775 @default.
- W2112363721 hasAuthorship W2112363721A5086652241 @default.
- W2112363721 hasAuthorship W2112363721A5089423258 @default.
- W2112363721 hasBestOaLocation W21123637211 @default.
- W2112363721 hasConcept C126322002 @default.
- W2112363721 hasConcept C134018914 @default.
- W2112363721 hasConcept C15490471 @default.
- W2112363721 hasConcept C169760540 @default.
- W2112363721 hasConcept C170493617 @default.
- W2112363721 hasConcept C171034665 @default.