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• W2112388217 abstract "The aim of the study was to examine the association between polymorphisms of DNA repair genes and chromosomal damage of 1,3-butadiene- (BD-) exposed workers. The study was conducted in 45 pairs of occupationally exposed workers in a BD product workshop and matched control workers in an administrative office and a circulatory water workshop in China. Newly developed biomarkers (micronuclei, MNi; nucleoplasmic bridges, NPBs; nuclear buds, NBUDs) in the cytokinesis-blocked micronucleus (CBMN) cytome assay were adopted to detect chromosomal damage. PCR and PCR-restriction fragment length polymorphism (RFLP) are adopted to analyze polymorphisms of DNA repair genes, such as X-ray repair cross-complementing Group 1 ( XRCC1 ), O 6 -methylguanine-DNA methyltransferase ( MGMT ), poly (adenosine diphosphate-ribose) polymerases ( ADPRT ), and apurinic/apyrimidinic endonucleases ( APE1 ). The BD-exposed workers exhibited increased frequencies of MNi and NPBs when compared to subjects in the control group. The results also show that the BD-exposed workers carrying XRCC1 diplotypes TCGA-CCGG (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mn>4.25</mml:mn><mml:mo>±</mml:mo><mml:mn>2.06</mml:mn><mml:mtext>‰</mml:mtext></mml:math>) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mtext>FR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.10</mml:mn></mml:math>, 95% CI: 1.03–4.28) and TCGG-TCGA (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mn>5.80</mml:mn><mml:mo>±</mml:mo><mml:mn>3.56</mml:mn><mml:mtext>‰</mml:mtext></mml:math>) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mtext>FR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.75</mml:mn></mml:math>, 95% CI: 0.76–2.65) had statistically higher NBUD frequencies than those who carried diplotype TCGG-TCGG (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mn>1.89</mml:mn><mml:mo>±</mml:mo><mml:mn>1.27</mml:mn><mml:mtext>‰</mml:mtext></mml:math>). Our study suggests that polymorphisms of XRCC1 gene may influence chromosomal damage in BD-exposed workers." @default.
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• W2112388217 date "2015-01-01" @default.
• W2112388217 modified "2023-10-17" @default.
• W2112388217 title "Association between Genetic Polymorphisms of DNA Repair Genes and Chromosomal Damage for 1,3-Butadiene-Exposed Workers in a Matched Study in China" @default.
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• W2112388217 doi "https://doi.org/10.1155/2015/234675" @default.
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