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- W2112426006 abstract "<h2>Abstract</h2> Forty patients with adenocarcinoma of the cecum who underwent right hemicolectomy received regional irradiation for 40–45 Gy/4–5 weeks and weekly 5-Fluorouracil (5-FU). Thirty-four patients received this adjuvant therapy: 12, 10, 5, 4 with Stage B2, B3, C2, C3, respectively, and 3 with abdominal metastasis. Another six patients were similarly treated for palliation because of tumor bed recurrences. Patients were followed for a median of 4 years, 21/31 patients in the adjuvant group with Stage B and C were free of disease with a median survival of 48 months (63% 5-year actuarial disease-free survival). The total local failure rate among the adjuvant group for Stage B and C was 431(13%) with local failure alone occurring in 1 of 4 patients (3%). In the patients treated at our Hospital, there was significant improvement in the 5-year actuarial survival (<i>p = 0.001</i>) for patients with lymph node metastases who received adjuvant irradiation compared to surgery-alone. Acute radiation enteritis occurred in seven out of 40 patients (17.5%) and was severe in 2 (5%). There were no delayed complications. We conclude that adjuvant therapy markedly lowered regional recurrence and seems to improve survival in patients with lymph node metastasis when compared to a group of patients treated by surgery alone in the same institution." @default.
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- W2112426006 date "1987-06-01" @default.
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- W2112426006 title "Regional adjuvant irradiation for adenocarcinoma of the cecum" @default.
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- W2112426006 doi "https://doi.org/10.1016/0360-3016(87)90097-6" @default.
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