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- W2112431270 abstract "Heparin 17–19k , (25, 50, and 100 ng), heparin 6k (50 and 100 ng), heparin 3k (50, 100, and 200 µg), chondroitin sulfates B (dermatan sulfate) (0.25, 0.5, and 1.0 µg), C (1 and 10 µg), and A (1 and 10 µg) each prolong the activated partial thromboplastin time (APTT) when preincubated with prothrombin to a greater extent than when preincubated with Factor II-deficient plasma prior to their mixing and subsequent additions of APTT reagent and Ca 2+ . In all cases statistical significance (p ≤ 0.05) was observed except with the 2 lower levels of heparin 3k . These results suggest that the glycosaminoglycans (GAGs) may exert a direct effect upon prothrombin (FII) in their anticoagulant activity. Pre mix tures of [(FII/25 ng H 17–19k ) + 447 mmol acetaldehyde (AcH)/L] as well as [(AcH/H) + FII] and [(FII/AcH) + H] each exert a synergistic anticoagulant effect upon APTT. At low AcH concentrations (44.7 mmol/L), neither a synergistic nor an additive effect is seen. H 6k and H 3k , on premixing with 447 mmol AcH/L, exhibit an additive effect on APTT prolongation but no synergism. Similarly, premixtures of CSB/447 mmol AcH/L/FII show a greater anticoagulant effect than do [(CSB/AcH) + FII] or [(FII/AcH) + CSB] premixtures. CSC–AcH and CSA–AcH patterns are analogous to those of CSB (DS). These data suggest the possibility that AcH, the primary product of ethanol metabolism, may serve as a crosslinking adduct with proteins, in this case, prothrombin, as well as GAGs. Thus ternary complexes between the zymogen form of coagulation factors, GAGs, and AcH are possible, further influencing coagulopathy.Key words: prothrombin, alcoholism, acetaldehyde, glycosaminoglycans, heparins, chondroitin sulfates." @default.
- W2112431270 created "2016-06-24" @default.
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- W2112431270 date "2005-05-01" @default.
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- W2112431270 title "The effect of glycosaminoglycans with acetaldehyde on the activation of prothrombin" @default.
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- W2112431270 doi "https://doi.org/10.1139/y05-017" @default.
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