FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112436639> ?p ?o ?g. }

• W2112436639 endingPage "1825" @default.
• W2112436639 startingPage "1819" @default.
• W2112436639 abstract "Abstract. The kidney efficiently salvages creatine from the urine; however, the mechanism(s) that mediates renal creatine reabsorption has not been investigated. This study characterizes the creatine transport mechanism in brush-border membrane vesicles isolated from the rat renal cortex. An osmolality plot revealed that creatine is transported into an osmotically active space and that it is also bound to the membranes. An inwardly directed NaCl gradient stimulated creatine uptake and the time course of uptake exhibited an overshoot phenomenon, which indicates the presence of an active process for creatine in these membranes. The uptake of creatine showed an absolute requirement for both Na+ and Cl-. The NaCl gradient—dependent creatine uptake was stimulated by a valinomycin-induced, inside-negative, K+-diffusion potential, which suggests that the uptake process is electrogenic. Stoichiometric analyses indicated a probable couple ratio of 2 Na+:1 Cl-:1 creatine molecule. The kinetic study showed that creatine is transported by a high-affinity system (Km of 15 μM). Creatine uptake was inhibited by a 100-fold excess of various compounds with the following potency order: cold creatine = guanidinopropionic acid > nipecotic acid > γ-aminobutyric acid (GABA) = β-alanine = betaine, whereas carnitine, glycine, taurine, and choline were without effect. This pattern of inhibition differs from that observed for GABA uptake (unlabeled GABA = GPA > β-alanine > nipecotic acid ≫ creatine). The conclusion drawn was that the apical membrane of the renal cortical tubules contains an active, high-affinity, electrogenic, 2 Na+/1 Cl-/creatine cotransporter." @default.
• W2112436639 created "2016-06-24" @default.
• W2112436639 creator A5011564557 @default.
• W2112436639 creator A5027288295 @default.
• W2112436639 creator A5042442070 @default.
• W2112436639 creator A5044864756 @default.
• W2112436639 creator A5075000701 @default.
• W2112436639 date "2001-09-01" @default.
• W2112436639 modified "2023-10-10" @default.
• W2112436639 title "Creatine Transport in Brush-Border Membrane Vesicles Isolated from Rat Kidney Cortex" @default.
• W2112436639 cites W108714150 @default.
• W2112436639 cites W1564178578 @default.
• W2112436639 cites W1889871926 @default.
• W2112436639 cites W1979236338 @default.
• W2112436639 cites W1992103299 @default.
• W2112436639 cites W1994878901 @default.
• W2112436639 cites W2011203433 @default.
• W2112436639 cites W2017300185 @default.
• W2112436639 cites W2017712790 @default.
• W2112436639 cites W2032084412 @default.
• W2112436639 cites W2037716390 @default.
• W2112436639 cites W2059787485 @default.
• W2112436639 cites W2061396409 @default.
• W2112436639 cites W2070936854 @default.
• W2112436639 cites W2073362201 @default.
• W2112436639 cites W2089256281 @default.
• W2112436639 cites W2091693868 @default.
• W2112436639 cites W2126713091 @default.
• W2112436639 cites W2178313645 @default.
• W2112436639 cites W2210555913 @default.
• W2112436639 cites W2261854986 @default.
• W2112436639 cites W2335870802 @default.
• W2112436639 cites W2405983227 @default.
• W2112436639 cites W4293247451 @default.
• W2112436639 doi "https://doi.org/10.1681/asn.v1291819" @default.
• W2112436639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11518774" @default.
• W2112436639 hasPublicationYear "2001" @default.
• W2112436639 type Work @default.
• W2112436639 sameAs 2112436639 @default.
• W2112436639 citedByCount "34" @default.
• W2112436639 countsByYear W21124366392012 @default.
• W2112436639 countsByYear W21124366392013 @default.
• W2112436639 countsByYear W21124366392014 @default.
• W2112436639 countsByYear W21124366392016 @default.
• W2112436639 countsByYear W21124366392017 @default.
• W2112436639 countsByYear W21124366392018 @default.
• W2112436639 countsByYear W21124366392019 @default.
• W2112436639 countsByYear W21124366392020 @default.
• W2112436639 countsByYear W21124366392021 @default.
• W2112436639 crossrefType "journal-article" @default.
• W2112436639 hasAuthorship W2112436639A5011564557 @default.
• W2112436639 hasAuthorship W2112436639A5027288295 @default.
• W2112436639 hasAuthorship W2112436639A5042442070 @default.
• W2112436639 hasAuthorship W2112436639A5044864756 @default.
• W2112436639 hasAuthorship W2112436639A5075000701 @default.
• W2112436639 hasBestOaLocation W21124366391 @default.
• W2112436639 hasConcept C126322002 @default.
• W2112436639 hasConcept C134018914 @default.
• W2112436639 hasConcept C170493617 @default.
• W2112436639 hasConcept C185592680 @default.
• W2112436639 hasConcept C2776055257 @default.
• W2112436639 hasConcept C2776219046 @default.
• W2112436639 hasConcept C2778577996 @default.
• W2112436639 hasConcept C2778626300 @default.
• W2112436639 hasConcept C2779701627 @default.
• W2112436639 hasConcept C2779896295 @default.
• W2112436639 hasConcept C2780091579 @default.
• W2112436639 hasConcept C2986317502 @default.
• W2112436639 hasConcept C41625074 @default.
• W2112436639 hasConcept C515207424 @default.
• W2112436639 hasConcept C55493867 @default.
• W2112436639 hasConcept C56906281 @default.
• W2112436639 hasConcept C71924100 @default.
• W2112436639 hasConcept C86803240 @default.
• W2112436639 hasConceptScore W2112436639C126322002 @default.
• W2112436639 hasConceptScore W2112436639C134018914 @default.
• W2112436639 hasConceptScore W2112436639C170493617 @default.
• W2112436639 hasConceptScore W2112436639C185592680 @default.
• W2112436639 hasConceptScore W2112436639C2776055257 @default.
• W2112436639 hasConceptScore W2112436639C2776219046 @default.
• W2112436639 hasConceptScore W2112436639C2778577996 @default.
• W2112436639 hasConceptScore W2112436639C2778626300 @default.
• W2112436639 hasConceptScore W2112436639C2779701627 @default.
• W2112436639 hasConceptScore W2112436639C2779896295 @default.
• W2112436639 hasConceptScore W2112436639C2780091579 @default.
• W2112436639 hasConceptScore W2112436639C2986317502 @default.
• W2112436639 hasConceptScore W2112436639C41625074 @default.
• W2112436639 hasConceptScore W2112436639C515207424 @default.
• W2112436639 hasConceptScore W2112436639C55493867 @default.
• W2112436639 hasConceptScore W2112436639C56906281 @default.
• W2112436639 hasConceptScore W2112436639C71924100 @default.
• W2112436639 hasConceptScore W2112436639C86803240 @default.
• W2112436639 hasIssue "9" @default.
• W2112436639 hasLocation W21124366391 @default.
• W2112436639 hasOpenAccess W2112436639 @default.
• W2112436639 hasPrimaryLocation W21124366391 @default.
• W2112436639 hasRelatedWork W1997689061 @default.
• W2112436639 hasRelatedWork W2007013063 @default.

• next