FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112439087> ?p ?o ?g. }

• W2112439087 endingPage "4849" @default.
• W2112439087 startingPage "4844" @default.
• W2112439087 abstract "Terminally differentiated post-mitotic cells are generally considered irreversibly developmentally locked, i.e. incapable of being reprogrammed in vivo into entirely different cell types. We found that brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully differentiated, highly specialized non-endodermal cells of the pharynx into fully differentiated intestinal cells in intact larvae and adult Caenorhabditis elegans. Stable expression of intestine-specific molecular markers parallels loss of markers for the original differentiated pharynx state; hence, there is no apparent requirement for a dedifferentiated intermediate during the transdifferentiation process. Based on high-resolution morphological characteristics, the transdifferentiated cells become remodeled to resemble typical intestinal cells at the level of both the cell surface and internal organelles. Thus, post-mitotic cells, though terminally differentiated, remain plastic to transdifferentiation across germ layer lineage boundaries and can be remodeled to adopt the characteristics of a new cell identity without removal of inhibitory factors. Our findings establish a simple model to investigate how cell context influences forced transdifferentiation of mature cells." @default.
• W2112439087 created "2016-06-24" @default.
• W2112439087 creator A5025554475 @default.
• W2112439087 creator A5026382723 @default.
• W2112439087 creator A5058876504 @default.
• W2112439087 creator A5059579408 @default.
• W2112439087 creator A5064591969 @default.
• W2112439087 date "2013-12-15" @default.
• W2112439087 modified "2023-09-30" @default.
• W2112439087 title "Transdifferentiation and remodeling of post-embryonic <i>C. elegans</i> cells by a single transcription factor" @default.
• W2112439087 cites W1989952069 @default.
• W2112439087 cites W1992727848 @default.
• W2112439087 cites W2002502183 @default.
• W2112439087 cites W2002879092 @default.
• W2112439087 cites W2033498063 @default.
• W2112439087 cites W2043426556 @default.
• W2112439087 cites W2056398241 @default.
• W2112439087 cites W2058051854 @default.
• W2112439087 cites W2068768873 @default.
• W2112439087 cites W2087345704 @default.
• W2112439087 cites W2093047307 @default.
• W2112439087 cites W2099871666 @default.
• W2112439087 cites W2100365580 @default.
• W2112439087 cites W2103464312 @default.
• W2112439087 cites W2109089699 @default.
• W2112439087 cites W2110359316 @default.
• W2112439087 cites W2113936637 @default.
• W2112439087 cites W2119612037 @default.
• W2112439087 cites W2121263384 @default.
• W2112439087 cites W2135718124 @default.
• W2112439087 cites W2149869194 @default.
• W2112439087 cites W2152672602 @default.
• W2112439087 cites W2154671341 @default.
• W2112439087 cites W2163127276 @default.
• W2112439087 cites W2186779150 @default.
• W2112439087 cites W91584898 @default.
• W2112439087 doi "https://doi.org/10.1242/dev.103010" @default.
• W2112439087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3848185" @default.
• W2112439087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24257624" @default.
• W2112439087 hasPublicationYear "2013" @default.
• W2112439087 type Work @default.
• W2112439087 sameAs 2112439087 @default.
• W2112439087 citedByCount "33" @default.
• W2112439087 countsByYear W21124390872014 @default.
• W2112439087 countsByYear W21124390872016 @default.
• W2112439087 countsByYear W21124390872017 @default.
• W2112439087 countsByYear W21124390872018 @default.
• W2112439087 countsByYear W21124390872019 @default.
• W2112439087 countsByYear W21124390872020 @default.
• W2112439087 countsByYear W21124390872021 @default.
• W2112439087 countsByYear W21124390872022 @default.
• W2112439087 countsByYear W21124390872023 @default.
• W2112439087 crossrefType "journal-article" @default.
• W2112439087 hasAuthorship W2112439087A5025554475 @default.
• W2112439087 hasAuthorship W2112439087A5026382723 @default.
• W2112439087 hasAuthorship W2112439087A5058876504 @default.
• W2112439087 hasAuthorship W2112439087A5059579408 @default.
• W2112439087 hasAuthorship W2112439087A5064591969 @default.
• W2112439087 hasBestOaLocation W21124390871 @default.
• W2112439087 hasConcept C104317684 @default.
• W2112439087 hasConcept C107459253 @default.
• W2112439087 hasConcept C145103041 @default.
• W2112439087 hasConcept C148738053 @default.
• W2112439087 hasConcept C18155467 @default.
• W2112439087 hasConcept C2778944004 @default.
• W2112439087 hasConcept C28328180 @default.
• W2112439087 hasConcept C54355233 @default.
• W2112439087 hasConcept C60870556 @default.
• W2112439087 hasConcept C86339819 @default.
• W2112439087 hasConcept C86803240 @default.
• W2112439087 hasConcept C95444343 @default.
• W2112439087 hasConceptScore W2112439087C104317684 @default.
• W2112439087 hasConceptScore W2112439087C107459253 @default.
• W2112439087 hasConceptScore W2112439087C145103041 @default.
• W2112439087 hasConceptScore W2112439087C148738053 @default.
• W2112439087 hasConceptScore W2112439087C18155467 @default.
• W2112439087 hasConceptScore W2112439087C2778944004 @default.
• W2112439087 hasConceptScore W2112439087C28328180 @default.
• W2112439087 hasConceptScore W2112439087C54355233 @default.
• W2112439087 hasConceptScore W2112439087C60870556 @default.
• W2112439087 hasConceptScore W2112439087C86339819 @default.
• W2112439087 hasConceptScore W2112439087C86803240 @default.
• W2112439087 hasConceptScore W2112439087C95444343 @default.
• W2112439087 hasIssue "24" @default.
• W2112439087 hasLocation W21124390871 @default.
• W2112439087 hasLocation W21124390872 @default.
• W2112439087 hasLocation W21124390873 @default.
• W2112439087 hasLocation W21124390874 @default.
• W2112439087 hasOpenAccess W2112439087 @default.
• W2112439087 hasPrimaryLocation W21124390871 @default.
• W2112439087 hasRelatedWork W2009519731 @default.
• W2112439087 hasRelatedWork W2053561999 @default.
• W2112439087 hasRelatedWork W2057702258 @default.
• W2112439087 hasRelatedWork W2100815688 @default.
• W2112439087 hasRelatedWork W2109538121 @default.
• W2112439087 hasRelatedWork W2366951433 @default.
• W2112439087 hasRelatedWork W3217227699 @default.
• W2112439087 hasRelatedWork W4226476957 @default.

• next