FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112492594> ?p ?o ?g. }

• W2112492594 endingPage "450" @default.
• W2112492594 startingPage "441" @default.
• W2112492594 abstract "SUMMARY Autosomal dominant polycystic kidney disease (ADPKD) results from loss-of-function mutations in PKD1 or PKD2. The products of these genes, the polycystins PC-1 and PC-2, form a transmembrane channel that is necessary for flow sensing by renal cilia. In C. elegans, the polycystin orthologs LOV-1 and PKD-2 function in sensory neurons that mediate male mating behavior. Here, we report that the novel single-pass membrane protein CWP-5 is necessary for polycystin signaling during the response step of mating behavior. As with the polycystins, CWP-5 localizes to neuronal cilia; this localization requires LOV-1. The response defect of cwp-5 mutants does not appear to result from disruption of ciliogenesis or polycystin localization. Instead, genetic and behavioral analyses indicate that CWP-5 represses a previously undescribed antagonistic effect of the polycystins on sensory function. Although cwp-5 does not have a primary-sequence ortholog in vertebrates, it has intriguing parallels with the autosomal recessive PKD gene FPC (also known as PKHD1). Together, this study identifies a new component of C. elegans polycystin signaling, demonstrates that the polycystins have a latent capacity to hinder sensory transduction, and suggests that aberrant functions of the polycystins could contribute to the pathogenesis of PKD." @default.
• W2112492594 created "2016-06-24" @default.
• W2112492594 creator A5018817530 @default.
• W2112492594 creator A5077264591 @default.
• W2112492594 date "2010-07-07" @default.
• W2112492594 modified "2023-09-23" @default.
• W2112492594 title "A latent capacity of the<i>C. elegans</i>polycystins to disrupt sensory transduction is repressed by the single-pass ciliary membrane protein CWP-5" @default.
• W2112492594 cites W1492104840 @default.
• W2112492594 cites W1903146305 @default.
• W2112492594 cites W1944127002 @default.
• W2112492594 cites W1949783943 @default.
• W2112492594 cites W1971197630 @default.
• W2112492594 cites W1977630266 @default.
• W2112492594 cites W1995714876 @default.
• W2112492594 cites W1999374220 @default.
• W2112492594 cites W2006380829 @default.
• W2112492594 cites W2014264816 @default.
• W2112492594 cites W2016268524 @default.
• W2112492594 cites W2029085436 @default.
• W2112492594 cites W2036145275 @default.
• W2112492594 cites W2041514166 @default.
• W2112492594 cites W2052986082 @default.
• W2112492594 cites W2057843157 @default.
• W2112492594 cites W2063639334 @default.
• W2112492594 cites W2065624887 @default.
• W2112492594 cites W2069464162 @default.
• W2112492594 cites W2073745454 @default.
• W2112492594 cites W2075591864 @default.
• W2112492594 cites W2080853555 @default.
• W2112492594 cites W2087491465 @default.
• W2112492594 cites W2089047063 @default.
• W2112492594 cites W2093964196 @default.
• W2112492594 cites W2095604113 @default.
• W2112492594 cites W2098955430 @default.
• W2112492594 cites W2116467841 @default.
• W2112492594 cites W2118697060 @default.
• W2112492594 cites W2119200120 @default.
• W2112492594 cites W2121190335 @default.
• W2112492594 cites W2127584818 @default.
• W2112492594 cites W2132115473 @default.
• W2112492594 cites W2135100794 @default.
• W2112492594 cites W2139555679 @default.
• W2112492594 cites W2143108257 @default.
• W2112492594 cites W2149183853 @default.
• W2112492594 cites W2164489472 @default.
• W2112492594 cites W2165466047 @default.
• W2112492594 cites W2170076805 @default.
• W2112492594 cites W4235438001 @default.
• W2112492594 doi "https://doi.org/10.1242/dmm.002816" @default.
• W2112492594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2898535" @default.
• W2112492594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20223935" @default.
• W2112492594 hasPublicationYear "2010" @default.
• W2112492594 type Work @default.
• W2112492594 sameAs 2112492594 @default.
• W2112492594 citedByCount "14" @default.
• W2112492594 countsByYear W21124925942013 @default.
• W2112492594 countsByYear W21124925942014 @default.
• W2112492594 countsByYear W21124925942015 @default.
• W2112492594 countsByYear W21124925942017 @default.
• W2112492594 countsByYear W21124925942018 @default.
• W2112492594 countsByYear W21124925942020 @default.
• W2112492594 countsByYear W21124925942021 @default.
• W2112492594 countsByYear W21124925942022 @default.
• W2112492594 crossrefType "journal-article" @default.
• W2112492594 hasAuthorship W2112492594A5018817530 @default.
• W2112492594 hasAuthorship W2112492594A5077264591 @default.
• W2112492594 hasBestOaLocation W21124925941 @default.
• W2112492594 hasConcept C100094513 @default.
• W2112492594 hasConcept C100773827 @default.
• W2112492594 hasConcept C104317684 @default.
• W2112492594 hasConcept C15152581 @default.
• W2112492594 hasConcept C170493617 @default.
• W2112492594 hasConcept C195267511 @default.
• W2112492594 hasConcept C24530287 @default.
• W2112492594 hasConcept C25194021 @default.
• W2112492594 hasConcept C2776266639 @default.
• W2112492594 hasConcept C2778944004 @default.
• W2112492594 hasConcept C2780091579 @default.
• W2112492594 hasConcept C2780145431 @default.
• W2112492594 hasConcept C50254741 @default.
• W2112492594 hasConcept C54355233 @default.
• W2112492594 hasConcept C55493867 @default.
• W2112492594 hasConcept C62478195 @default.
• W2112492594 hasConcept C86803240 @default.
• W2112492594 hasConcept C95444343 @default.
• W2112492594 hasConceptScore W2112492594C100094513 @default.
• W2112492594 hasConceptScore W2112492594C100773827 @default.
• W2112492594 hasConceptScore W2112492594C104317684 @default.
• W2112492594 hasConceptScore W2112492594C15152581 @default.
• W2112492594 hasConceptScore W2112492594C170493617 @default.
• W2112492594 hasConceptScore W2112492594C195267511 @default.
• W2112492594 hasConceptScore W2112492594C24530287 @default.
• W2112492594 hasConceptScore W2112492594C25194021 @default.
• W2112492594 hasConceptScore W2112492594C2776266639 @default.
• W2112492594 hasConceptScore W2112492594C2778944004 @default.
• W2112492594 hasConceptScore W2112492594C2780091579 @default.
• W2112492594 hasConceptScore W2112492594C2780145431 @default.
• W2112492594 hasConceptScore W2112492594C50254741 @default.

• next