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• W2112499150 abstract "Objectives To evaluate the first prospective screening program in China for control of α and β-thalassemia in the population of pregnant couples. Methods During the period between January 1993 and December 2003, a hospital-based preventive program was conducted at the biggest birth center in Guangzhou, with 1/17 of all deliveries in this city referred annually by use of conventional heterozygote screening strategy in combination with the system of regular healthcare examination in pregnancy. Results The screened records included 49 221 pregnant women, and 4503 husbands of the pregnant women showed positive on the screening test. Of the at-risk couples, there were 198 for α-thal (4.4%) and 83 for β-thal (1.8%), respectively. Genetic counseling was offered to all at-risk couples and a successful prenatal diagnosis was performed for 269 out of 281 (95.7%) for α- or β-thal major, with the remaining 12 couples refusing to accept prenatal diagnosis. Out of 187 pregnancies at risk for homozygous α0-thal and 82 at risk for β-thal major, 51 hydrops fetalis with Hb Bart's and 18 β-thal major were identified. All pregnancies with affected fetuses were voluntarily terminated, leading to a marked reduction of severe α- and β-thal births at this hospital since the program has been launched. Conclusions Our hospital-based program proved to be highly effective in reducing severe thals in pregnant populations. Copyright © 2005 John Wiley & Sons, Ltd." @default.
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• W2112499150 date "2005-01-01" @default.
• W2112499150 modified "2023-10-15" @default.
• W2112499150 title "Carrier screening for ?- and ?-thalassemia in pregnancy: the results of an 11-year prospective program in Guangzhou Maternal and Neonatal hospital" @default.
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• W2112499150 doi "https://doi.org/10.1002/pd.1079" @default.
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