Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112506019> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2112506019 endingPage "421" @default.
- W2112506019 startingPage "417" @default.
- W2112506019 abstract "Abstract AM 92016(1-(4-methanesulphonamidophenoxy)-3-(N-methyl-3–4-dichlorophenethylamino)-2-propanol benzoic acid salt), an oxypropanolamine analogue of sotalol, has been shown to possess Class III antiarrhythmic properties in-vitro at concentrations showing 1000 times more potency than sotalol. The aim of this study was to characterize the effects of AM 92016 in-vivo. When administered to anaesthetized guinea-pigs, AM 92016 (10 μg kg−1-5 mg kg−1) significantly increased heart rate, systolic arterial blood pressure, left ventricular systolic pressure and the contractile index dp/dtmax. AM 92016 also significantly decreased the QT interval of the electrocardiogram from 135 ± 10 to 105 ± 4 ms (5 mg kg−1). The time to onset of the first arrhythmia and ventricular fibrillation, induced by intravenous infusion of ouabain, was shortened in the presence of AM 92016. Ouabain-induced ventricular fibrillation occurred at 18 ± 5 and 12 ± 3 min (P < 005) in control and AM 92016-(1 mg kg−1) treated guinea-pigs, respectively. An infusion of AM 92016 (2.5 μg kg−1 min−1) to anaesthetized pigs significantly increased the total number of arrhythmias occurring following coronary artery occlusion from 266 ·26 in control pigs to 535 ± 148 (P < 005) in those receiving AM 92016. The time to onset of ventricular fibrillation was also significantly reduced in anaesthetized pigs from 24 ± 1 to 18 ± 3 min in the presence of AM 92016. The drug did not change haemodynamics in the anaesthetized pig. We conclude that AM 92016 exhibited proarrhythmic rather than antiarrhythmic activity when administered in-vivo to either guinea-pigs or pigs." @default.
- W2112506019 created "2016-06-24" @default.
- W2112506019 creator A5071561367 @default.
- W2112506019 creator A5081273637 @default.
- W2112506019 creator A5083939564 @default.
- W2112506019 date "1996-04-01" @default.
- W2112506019 modified "2023-09-26" @default.
- W2112506019 title "The In-vivo Cardiovascular Effects of a Putative Class III Anti-arrhythmic Drug, AM 92016" @default.
- W2112506019 cites W1974127616 @default.
- W2112506019 cites W2050809036 @default.
- W2112506019 cites W2058311825 @default.
- W2112506019 cites W2067921041 @default.
- W2112506019 cites W2073242964 @default.
- W2112506019 cites W2085773239 @default.
- W2112506019 cites W2086032237 @default.
- W2112506019 cites W2133488495 @default.
- W2112506019 cites W4236284766 @default.
- W2112506019 doi "https://doi.org/10.1111/j.2042-7158.1996.tb05944.x" @default.
- W2112506019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8794994" @default.
- W2112506019 hasPublicationYear "1996" @default.
- W2112506019 type Work @default.
- W2112506019 sameAs 2112506019 @default.
- W2112506019 citedByCount "5" @default.
- W2112506019 countsByYear W21125060192015 @default.
- W2112506019 countsByYear W21125060192017 @default.
- W2112506019 crossrefType "journal-article" @default.
- W2112506019 hasAuthorship W2112506019A5071561367 @default.
- W2112506019 hasAuthorship W2112506019A5081273637 @default.
- W2112506019 hasAuthorship W2112506019A5083939564 @default.
- W2112506019 hasBestOaLocation W21125060191 @default.
- W2112506019 hasConcept C118441451 @default.
- W2112506019 hasConcept C126322002 @default.
- W2112506019 hasConcept C150903083 @default.
- W2112506019 hasConcept C164705383 @default.
- W2112506019 hasConcept C178790620 @default.
- W2112506019 hasConcept C178853913 @default.
- W2112506019 hasConcept C185592680 @default.
- W2112506019 hasConcept C202751555 @default.
- W2112506019 hasConcept C207001950 @default.
- W2112506019 hasConcept C2776639339 @default.
- W2112506019 hasConcept C2777953023 @default.
- W2112506019 hasConcept C2779133857 @default.
- W2112506019 hasConcept C2779161974 @default.
- W2112506019 hasConcept C2781005686 @default.
- W2112506019 hasConcept C42219234 @default.
- W2112506019 hasConcept C537181965 @default.
- W2112506019 hasConcept C55493867 @default.
- W2112506019 hasConcept C57992300 @default.
- W2112506019 hasConcept C71924100 @default.
- W2112506019 hasConcept C84393581 @default.
- W2112506019 hasConcept C86803240 @default.
- W2112506019 hasConceptScore W2112506019C118441451 @default.
- W2112506019 hasConceptScore W2112506019C126322002 @default.
- W2112506019 hasConceptScore W2112506019C150903083 @default.
- W2112506019 hasConceptScore W2112506019C164705383 @default.
- W2112506019 hasConceptScore W2112506019C178790620 @default.
- W2112506019 hasConceptScore W2112506019C178853913 @default.
- W2112506019 hasConceptScore W2112506019C185592680 @default.
- W2112506019 hasConceptScore W2112506019C202751555 @default.
- W2112506019 hasConceptScore W2112506019C207001950 @default.
- W2112506019 hasConceptScore W2112506019C2776639339 @default.
- W2112506019 hasConceptScore W2112506019C2777953023 @default.
- W2112506019 hasConceptScore W2112506019C2779133857 @default.
- W2112506019 hasConceptScore W2112506019C2779161974 @default.
- W2112506019 hasConceptScore W2112506019C2781005686 @default.
- W2112506019 hasConceptScore W2112506019C42219234 @default.
- W2112506019 hasConceptScore W2112506019C537181965 @default.
- W2112506019 hasConceptScore W2112506019C55493867 @default.
- W2112506019 hasConceptScore W2112506019C57992300 @default.
- W2112506019 hasConceptScore W2112506019C71924100 @default.
- W2112506019 hasConceptScore W2112506019C84393581 @default.
- W2112506019 hasConceptScore W2112506019C86803240 @default.
- W2112506019 hasIssue "4" @default.
- W2112506019 hasLocation W21125060191 @default.
- W2112506019 hasLocation W21125060192 @default.
- W2112506019 hasOpenAccess W2112506019 @default.
- W2112506019 hasPrimaryLocation W21125060191 @default.
- W2112506019 hasRelatedWork W129965995 @default.
- W2112506019 hasRelatedWork W1911538625 @default.
- W2112506019 hasRelatedWork W1971696613 @default.
- W2112506019 hasRelatedWork W1973331029 @default.
- W2112506019 hasRelatedWork W2038661164 @default.
- W2112506019 hasRelatedWork W2090701603 @default.
- W2112506019 hasRelatedWork W2112506019 @default.
- W2112506019 hasRelatedWork W2371249220 @default.
- W2112506019 hasRelatedWork W2383375557 @default.
- W2112506019 hasRelatedWork W2391865482 @default.
- W2112506019 hasVolume "48" @default.
- W2112506019 isParatext "false" @default.
- W2112506019 isRetracted "false" @default.
- W2112506019 magId "2112506019" @default.
- W2112506019 workType "article" @default.