FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112545761> ?p ?o ?g. }

• W2112545761 endingPage "130" @default.
• W2112545761 startingPage "124" @default.
• W2112545761 abstract "Cows' milk sensitive reflux oesophagitis is an emerging clinical entity in children, normally indistinguishable from primary gastro-oesophageal reflux (GOR) apart from the response to dietary antigen exclusion. It is conjectural whether a tendency towards mucosal eosinophilia distinguishes this group from primary GOR.To determine whether there may be differences in the mucosal lesion within the oesophagus in those children with reflux in association with cows' milk induced small bowel pathology, particularly in relation to the eosinophil chemokine eotaxin.A total of 29 children underwent endoscopic assessment, including nine with cows' milk sensitive enteropathy (CMSE) and associated GOR, seven histologically normal controls, six with primary GOR, and seven disease controls. Oesophageal biopsy specimens were examined immunohistochemically for the chemokines eotaxin and MCP-2, and T cell lineage and activation markers.Strong upregulation of eotaxin expression, limited to basal and papillary epithelium, occurred in all CMSE patients. By contrast, weak expression was seen in a minority of controls and in 50% of primary GOR patients. Infiltration of CD3, CD4, and CD8 lymphocytes occurred in similar distribution in CMSE patients, significantly increased above controls. Significant upregulation of activation markers (CD25, HLA-DR) was also seen in the CMSE group within basal and papillary epithelium compared to controls and primary GOR.Basal and papillary epithelial eotaxin expression, with focal lymphocyte activation, was seen in infants with CMSE associated GOR. This preliminary study provides early evidence to suggest a pathogenesis distinct from primary GOR, in which specific recruitment of T cells and eosinophils may contribute to oesophageal dysmotility." @default.
• W2112545761 created "2016-06-24" @default.
• W2112545761 creator A5004712469 @default.
• W2112545761 creator A5038289868 @default.
• W2112545761 creator A5047083390 @default.
• W2112545761 creator A5055139405 @default.
• W2112545761 creator A5055204215 @default.
• W2112545761 creator A5057155750 @default.
• W2112545761 creator A5060937377 @default.
• W2112545761 creator A5061753967 @default.
• W2112545761 date "2002-08-01" @default.
• W2112545761 modified "2023-09-27" @default.
• W2112545761 title "Upregulated eotaxin expression and T cell infiltration in the basal and papillary epithelium in cows' milk associated reflux oesophagitis" @default.
• W2112545761 cites W1529615153 @default.
• W2112545761 cites W1981343916 @default.
• W2112545761 cites W1987108574 @default.
• W2112545761 cites W1995303508 @default.
• W2112545761 cites W1999641867 @default.
• W2112545761 cites W2004216239 @default.
• W2112545761 cites W2007323732 @default.
• W2112545761 cites W2010771602 @default.
• W2112545761 cites W2023520187 @default.
• W2112545761 cites W2033306128 @default.
• W2112545761 cites W2040288515 @default.
• W2112545761 cites W2048403124 @default.
• W2112545761 cites W2048988599 @default.
• W2112545761 cites W2060173029 @default.
• W2112545761 cites W2082666730 @default.
• W2112545761 cites W2084522938 @default.
• W2112545761 cites W2095309729 @default.
• W2112545761 cites W2105545427 @default.
• W2112545761 cites W2110075931 @default.
• W2112545761 cites W2110316150 @default.
• W2112545761 cites W2111944050 @default.
• W2112545761 cites W2115429879 @default.
• W2112545761 cites W2129769279 @default.
• W2112545761 cites W2159791496 @default.
• W2112545761 cites W2160129587 @default.
• W2112545761 cites W2169556664 @default.
• W2112545761 cites W2323763104 @default.
• W2112545761 cites W2326465921 @default.
• W2112545761 cites W2327249603 @default.
• W2112545761 cites W39248836 @default.
• W2112545761 doi "https://doi.org/10.1136/adc.87.2.124" @default.
• W2112545761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1719188" @default.
• W2112545761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12138061" @default.
• W2112545761 hasPublicationYear "2002" @default.
• W2112545761 type Work @default.
• W2112545761 sameAs 2112545761 @default.
• W2112545761 citedByCount "30" @default.
• W2112545761 countsByYear W21125457612012 @default.
• W2112545761 countsByYear W21125457612013 @default.
• W2112545761 countsByYear W21125457612014 @default.
• W2112545761 countsByYear W21125457612015 @default.
• W2112545761 countsByYear W21125457612017 @default.
• W2112545761 countsByYear W21125457612020 @default.
• W2112545761 crossrefType "journal-article" @default.
• W2112545761 hasAuthorship W2112545761A5004712469 @default.
• W2112545761 hasAuthorship W2112545761A5038289868 @default.
• W2112545761 hasAuthorship W2112545761A5047083390 @default.
• W2112545761 hasAuthorship W2112545761A5055139405 @default.
• W2112545761 hasAuthorship W2112545761A5055204215 @default.
• W2112545761 hasAuthorship W2112545761A5057155750 @default.
• W2112545761 hasAuthorship W2112545761A5060937377 @default.
• W2112545761 hasAuthorship W2112545761A5061753967 @default.
• W2112545761 hasBestOaLocation W21125457611 @default.
• W2112545761 hasConcept C126322002 @default.
• W2112545761 hasConcept C13373296 @default.
• W2112545761 hasConcept C142724271 @default.
• W2112545761 hasConcept C203014093 @default.
• W2112545761 hasConcept C2776042228 @default.
• W2112545761 hasConcept C2776914184 @default.
• W2112545761 hasConcept C2777037409 @default.
• W2112545761 hasConcept C2777129736 @default.
• W2112545761 hasConcept C2777716647 @default.
• W2112545761 hasConcept C2778024521 @default.
• W2112545761 hasConcept C2779306644 @default.
• W2112545761 hasConcept C2780942790 @default.
• W2112545761 hasConcept C71924100 @default.
• W2112545761 hasConceptScore W2112545761C126322002 @default.
• W2112545761 hasConceptScore W2112545761C13373296 @default.
• W2112545761 hasConceptScore W2112545761C142724271 @default.
• W2112545761 hasConceptScore W2112545761C203014093 @default.
• W2112545761 hasConceptScore W2112545761C2776042228 @default.
• W2112545761 hasConceptScore W2112545761C2776914184 @default.
• W2112545761 hasConceptScore W2112545761C2777037409 @default.
• W2112545761 hasConceptScore W2112545761C2777129736 @default.
• W2112545761 hasConceptScore W2112545761C2777716647 @default.
• W2112545761 hasConceptScore W2112545761C2778024521 @default.
• W2112545761 hasConceptScore W2112545761C2779306644 @default.
• W2112545761 hasConceptScore W2112545761C2780942790 @default.
• W2112545761 hasConceptScore W2112545761C71924100 @default.
• W2112545761 hasIssue "2" @default.
• W2112545761 hasLocation W21125457611 @default.
• W2112545761 hasLocation W21125457612 @default.
• W2112545761 hasLocation W21125457613 @default.
• W2112545761 hasLocation W21125457614 @default.
• W2112545761 hasLocation W21125457615 @default.

• next