Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112560233> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2112560233 endingPage "389" @default.
- W2112560233 startingPage "385" @default.
- W2112560233 abstract "In our previous in vitro micronucleus (MN) study, we showed that aneugens, in addition to inducing micronuclei, induce a higher frequency of polynuclear (PN) and mitotic (M) cells than clastogens. We hypothesized that the frequency of PN and M cells induced can distinguish aneugens from clastogens. To test the hypothesis, we conducted the micronucleus tests with mitomycin C (MMC), N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), vincristine (VINC) and diazepam in a Chinese hamster cell line (CHL) and VINC, benzo[a]pyrene (BP) and 7,12-dimethylbenz[a]anthracene (DMBA) in a subclone of V79 cells (V79-MZ). All chemicals increased the frequency of M cells with statistical significance. All chemicals except diazepam increased the frequency of PN cells with statistical significance. Three of the aneugens (VINC, BP and DMBA) induced ≥200 PN cells/1000 cells while the clastogens (MNNG and MMC) induced 100 PN cells at most. All the aneugens but no clastogens significantly increased the frequency of M cells. We propose that micronucleus test-positive chemicals that induce ≥200 PN cells/1000 cells and significantly increase the frequency of M cells are aneugens and those that induce at most 100 PN cells/1000 cells and do not significantly increase the frequency of M cells in our MN test protocol are clastogens. Diazepam, however, did not induce PN cells, although it increased the frequency of M cells dose dependently. We explain this fact in relation to diazepam's mode of action. Our proposal suggests a quick, easy and practical way to distinguish aneugens from clastogens for screening purposes." @default.
- W2112560233 created "2016-06-24" @default.
- W2112560233 creator A5017287832 @default.
- W2112560233 date "1999-07-01" @default.
- W2112560233 modified "2023-09-24" @default.
- W2112560233 title "A proposal for a simple way to distinguish aneugens from clastogens in the in vitro micronucleus test" @default.
- W2112560233 cites W1967066275 @default.
- W2112560233 cites W1983263107 @default.
- W2112560233 cites W1983338587 @default.
- W2112560233 cites W1996102265 @default.
- W2112560233 cites W2018112799 @default.
- W2112560233 cites W2026600949 @default.
- W2112560233 cites W2027355586 @default.
- W2112560233 cites W2031286860 @default.
- W2112560233 cites W2036895138 @default.
- W2112560233 cites W2052825715 @default.
- W2112560233 cites W2055612491 @default.
- W2112560233 cites W2059613902 @default.
- W2112560233 cites W2067475796 @default.
- W2112560233 cites W2069170671 @default.
- W2112560233 cites W2081908406 @default.
- W2112560233 cites W2082232487 @default.
- W2112560233 cites W2127279305 @default.
- W2112560233 cites W2131504112 @default.
- W2112560233 cites W2137497507 @default.
- W2112560233 cites W2151891995 @default.
- W2112560233 cites W2156150502 @default.
- W2112560233 cites W2399785260 @default.
- W2112560233 doi "https://doi.org/10.1093/mutage/14.4.385" @default.
- W2112560233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10390505" @default.
- W2112560233 hasPublicationYear "1999" @default.
- W2112560233 type Work @default.
- W2112560233 sameAs 2112560233 @default.
- W2112560233 citedByCount "33" @default.
- W2112560233 countsByYear W21125602332012 @default.
- W2112560233 countsByYear W21125602332015 @default.
- W2112560233 countsByYear W21125602332017 @default.
- W2112560233 countsByYear W21125602332018 @default.
- W2112560233 countsByYear W21125602332019 @default.
- W2112560233 countsByYear W21125602332020 @default.
- W2112560233 crossrefType "journal-article" @default.
- W2112560233 hasAuthorship W2112560233A5017287832 @default.
- W2112560233 hasBestOaLocation W21125602331 @default.
- W2112560233 hasConcept C121608353 @default.
- W2112560233 hasConcept C141710004 @default.
- W2112560233 hasConcept C153911025 @default.
- W2112560233 hasConcept C178790620 @default.
- W2112560233 hasConcept C185592680 @default.
- W2112560233 hasConcept C202751555 @default.
- W2112560233 hasConcept C2777755551 @default.
- W2112560233 hasConcept C2778575167 @default.
- W2112560233 hasConcept C2778938436 @default.
- W2112560233 hasConcept C29730261 @default.
- W2112560233 hasConcept C36681516 @default.
- W2112560233 hasConcept C45080847 @default.
- W2112560233 hasConcept C54355233 @default.
- W2112560233 hasConcept C555283112 @default.
- W2112560233 hasConcept C86803240 @default.
- W2112560233 hasConcept C98274493 @default.
- W2112560233 hasConceptScore W2112560233C121608353 @default.
- W2112560233 hasConceptScore W2112560233C141710004 @default.
- W2112560233 hasConceptScore W2112560233C153911025 @default.
- W2112560233 hasConceptScore W2112560233C178790620 @default.
- W2112560233 hasConceptScore W2112560233C185592680 @default.
- W2112560233 hasConceptScore W2112560233C202751555 @default.
- W2112560233 hasConceptScore W2112560233C2777755551 @default.
- W2112560233 hasConceptScore W2112560233C2778575167 @default.
- W2112560233 hasConceptScore W2112560233C2778938436 @default.
- W2112560233 hasConceptScore W2112560233C29730261 @default.
- W2112560233 hasConceptScore W2112560233C36681516 @default.
- W2112560233 hasConceptScore W2112560233C45080847 @default.
- W2112560233 hasConceptScore W2112560233C54355233 @default.
- W2112560233 hasConceptScore W2112560233C555283112 @default.
- W2112560233 hasConceptScore W2112560233C86803240 @default.
- W2112560233 hasConceptScore W2112560233C98274493 @default.
- W2112560233 hasIssue "4" @default.
- W2112560233 hasLocation W21125602331 @default.
- W2112560233 hasLocation W21125602332 @default.
- W2112560233 hasOpenAccess W2112560233 @default.
- W2112560233 hasPrimaryLocation W21125602331 @default.
- W2112560233 hasRelatedWork W1091013801 @default.
- W2112560233 hasRelatedWork W2037592385 @default.
- W2112560233 hasRelatedWork W2053747521 @default.
- W2112560233 hasRelatedWork W2091355127 @default.
- W2112560233 hasRelatedWork W2112313957 @default.
- W2112560233 hasRelatedWork W2112560233 @default.
- W2112560233 hasRelatedWork W2154771600 @default.
- W2112560233 hasRelatedWork W2162213622 @default.
- W2112560233 hasRelatedWork W2409139638 @default.
- W2112560233 hasRelatedWork W809441913 @default.
- W2112560233 hasVolume "14" @default.
- W2112560233 isParatext "false" @default.
- W2112560233 isRetracted "false" @default.
- W2112560233 magId "2112560233" @default.
- W2112560233 workType "article" @default.