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• W2112561353 endingPage "100" @default.
• W2112561353 startingPage "90" @default.
• W2112561353 abstract "Phosducin (PDC) has been shown in structural and biochemical experiments to bind the Gβγ subunit of heterotrimeric G-proteins. A proposed function of PDC and phosducin-like protein (PDCL) is the sequestration of “free” Gβγ from the plasma membrane, thereby terminating signaling by Gβγ. The functional impact of heterologously expressed PDC and PDCL on N-type calcium channel (Ca_V2.2) modulation was examined in sympathetic neurons, isolated from rat superior cervical ganglia, using whole-cell voltage clamp. Expression of PDC and PDCL attenuated voltage-dependent inhibition of N-type calcium channels, a Gβγ-dependent process, in a time-dependent fashion. Calcium current inhibition after short-term exposure to norepinephrine was minimally altered by PDC or PDCL expression. However, in the continued presence of norepinephrine, PDC or PDCL relieved calcium channel inhibition compared with control neurons. We observed similar results after activation of heterologously expressed metabotropic glutamate receptors with 100 μM l-glutamate. Neurons expressing PDC or PDCL maintained suppression of inhibition after re-exposure to agonist. Unlike other Gβγ sequestering proteins that abolish the short-term inhibition of Ca²⁺ channels, PDC and PDCL require prolonged agonist exposure before effects on modulation are realized." @default.
• W2112561353 created "2016-06-24" @default.
• W2112561353 creator A5027622185 @default.
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• W2112561353 date "2006-04-11" @default.
• W2112561353 modified "2023-09-27" @default.
• W2112561353 title "Phosducin and Phosducin-like Protein Attenuate G-Protein-Coupled Receptor-Mediated Inhibition of Voltage-Gated Calcium Channels in Rat Sympathetic Neurons" @default.
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• W2112561353 doi "https://doi.org/10.1124/mol.105.021394" @default.
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• W2112561353 hasPublicationYear "2006" @default.
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