Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112568810> ?p ?o ?g. }
- W2112568810 endingPage "3557" @default.
- W2112568810 startingPage "3551" @default.
- W2112568810 abstract "Abstract Matrix metalloproteinases (MMP) degrade various components of the extracellular matrix, and their overexpression has been implicated in tumor progression. Nonsynonymous single nucleotide polymorphisms (SNPs) lead to amino acid substitutions that can alter the function of the encoded protein. We evaluated the associations of six nonsynonymous SNPs in the MMP3, MMP8, and MMP9 genes with skin cancer risk in a nested case-control study of Caucasians within the Nurses' Health Study among 218 melanoma cases, 285 squamous cell carcinoma (SCC) cases, 300 basal cell carcinoma (BCC) cases, and 870 normal controls. We observed that the MMP9 Arg668Gln polymorphism was significantly associated with a decreased risk of SCC. Compared with the Arg/Arg group, the multivariate odds ratio was 0.67 (95% confidence interval, 0.47-0.97) for the Arg/Gln group and 0.21 (95% confidence interval, 0.05-0.97) for the Gln/Gln group (Ptrend = 0.004). We did not observe any association of this SNP with the risks of melanoma and basal cell carcinoma. No associations were found for other SNPs with skin cancer risk. This study provides evidence for the contribution of the MMP9 Arg668Gln to SCC development. (Cancer Epidemiol Biomarkers Prev 2008;17(12):3551–7)" @default.
- W2112568810 created "2016-06-24" @default.
- W2112568810 creator A5015017082 @default.
- W2112568810 creator A5031168277 @default.
- W2112568810 creator A5068141497 @default.
- W2112568810 creator A5080921373 @default.
- W2112568810 date "2008-12-01" @default.
- W2112568810 modified "2023-09-25" @default.
- W2112568810 title "Missense Polymorphisms in Matrix Metalloproteinase Genes and Skin Cancer Risk" @default.
- W2112568810 cites W1969204559 @default.
- W2112568810 cites W1971050728 @default.
- W2112568810 cites W1978591675 @default.
- W2112568810 cites W1986529293 @default.
- W2112568810 cites W1991449455 @default.
- W2112568810 cites W1992200462 @default.
- W2112568810 cites W1999887312 @default.
- W2112568810 cites W2003500892 @default.
- W2112568810 cites W2008996296 @default.
- W2112568810 cites W2009168769 @default.
- W2112568810 cites W2016547017 @default.
- W2112568810 cites W2017448700 @default.
- W2112568810 cites W2017517432 @default.
- W2112568810 cites W2032645976 @default.
- W2112568810 cites W2039919378 @default.
- W2112568810 cites W2042333083 @default.
- W2112568810 cites W2052626837 @default.
- W2112568810 cites W2053724807 @default.
- W2112568810 cites W2056117234 @default.
- W2112568810 cites W2057896496 @default.
- W2112568810 cites W2063295519 @default.
- W2112568810 cites W2071507111 @default.
- W2112568810 cites W2080357756 @default.
- W2112568810 cites W2104008520 @default.
- W2112568810 cites W2111663735 @default.
- W2112568810 cites W2123340910 @default.
- W2112568810 cites W2123943285 @default.
- W2112568810 cites W2135124706 @default.
- W2112568810 cites W2143210482 @default.
- W2112568810 cites W2143238378 @default.
- W2112568810 cites W2146440075 @default.
- W2112568810 cites W2147265607 @default.
- W2112568810 cites W2148383568 @default.
- W2112568810 cites W2152750025 @default.
- W2112568810 cites W2154401382 @default.
- W2112568810 cites W2163644607 @default.
- W2112568810 cites W2163962712 @default.
- W2112568810 cites W2166963888 @default.
- W2112568810 cites W2167257571 @default.
- W2112568810 cites W2169085013 @default.
- W2112568810 cites W4250908540 @default.
- W2112568810 cites W4254753097 @default.
- W2112568810 doi "https://doi.org/10.1158/1055-9965.epi-08-0606" @default.
- W2112568810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2664625" @default.
- W2112568810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19064570" @default.
- W2112568810 hasPublicationYear "2008" @default.
- W2112568810 type Work @default.
- W2112568810 sameAs 2112568810 @default.
- W2112568810 citedByCount "23" @default.
- W2112568810 countsByYear W21125688102012 @default.
- W2112568810 countsByYear W21125688102013 @default.
- W2112568810 countsByYear W21125688102014 @default.
- W2112568810 countsByYear W21125688102016 @default.
- W2112568810 countsByYear W21125688102017 @default.
- W2112568810 countsByYear W21125688102018 @default.
- W2112568810 countsByYear W21125688102019 @default.
- W2112568810 countsByYear W21125688102021 @default.
- W2112568810 countsByYear W21125688102022 @default.
- W2112568810 crossrefType "journal-article" @default.
- W2112568810 hasAuthorship W2112568810A5015017082 @default.
- W2112568810 hasAuthorship W2112568810A5031168277 @default.
- W2112568810 hasAuthorship W2112568810A5068141497 @default.
- W2112568810 hasAuthorship W2112568810A5080921373 @default.
- W2112568810 hasBestOaLocation W21125688101 @default.
- W2112568810 hasConcept C104317684 @default.
- W2112568810 hasConcept C126322002 @default.
- W2112568810 hasConcept C135763542 @default.
- W2112568810 hasConcept C139275648 @default.
- W2112568810 hasConcept C141231307 @default.
- W2112568810 hasConcept C143998085 @default.
- W2112568810 hasConcept C146304588 @default.
- W2112568810 hasConcept C149904235 @default.
- W2112568810 hasConcept C153209595 @default.
- W2112568810 hasConcept C156957248 @default.
- W2112568810 hasConcept C2778804307 @default.
- W2112568810 hasConcept C3019992690 @default.
- W2112568810 hasConcept C44249647 @default.
- W2112568810 hasConcept C54355233 @default.
- W2112568810 hasConcept C71924100 @default.
- W2112568810 hasConcept C86803240 @default.
- W2112568810 hasConceptScore W2112568810C104317684 @default.
- W2112568810 hasConceptScore W2112568810C126322002 @default.
- W2112568810 hasConceptScore W2112568810C135763542 @default.
- W2112568810 hasConceptScore W2112568810C139275648 @default.
- W2112568810 hasConceptScore W2112568810C141231307 @default.
- W2112568810 hasConceptScore W2112568810C143998085 @default.
- W2112568810 hasConceptScore W2112568810C146304588 @default.
- W2112568810 hasConceptScore W2112568810C149904235 @default.
- W2112568810 hasConceptScore W2112568810C153209595 @default.