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• W2112569051 abstract "ABSTRACT Increased lymphocyte turnover is a hallmark of pathogenic lentiviral infection. To investigate perturbations in lymphocyte dynamics in natural hosts with nonpathogenic simian immunodeficiency virus (SIV) infection, the nucleoside analog bromodeoxyuridine (BrdU) was administered to six naturally SIV-infected and five SIV-negative sooty mangabeys. As a measure of lymphocyte turnover, we estimated the mean death rate by fitting a mathematical model to the fraction of BrdU-labeled cells during a 2-week labeling and a median 10-week delabeling period. Despite significantly lower total T- and B-lymphocyte counts in SIV-infected sooty mangabeys than in SIV-negative mangabeys, the turnover rate of B lymphocytes and CD4 + and CD8 + T lymphocytes was not increased in the SIV-infected animals. A small, rapidly proliferating CD45RA + memory subset and a large, slower-proliferating CD45RA − central memory subset of CD4 + T lymphocytes identified in the peripheral blood of sooty mangabeys also did not show evidence of increased turnover in the context of SIV infection. Independently of SIV infection, the turnover of CD4 + T lymphocytes in sooty mangabeys was significantly higher ( P < 0.01) than that of CD8 + T lymphocytes, a finding hitherto not reported in rhesus macaques or humans. The absence of aberrant T-lymphocyte turnover along with an inherently high rate of CD4 + T-lymphocyte turnover may help to preserve the pool of central memory CD4 + T lymphocytes in viremic SIV-infected sooty mangabeys and protect against progression to AIDS." @default.
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• W2112569051 date "2008-02-01" @default.
• W2112569051 modified "2023-10-17" @default.
• W2112569051 title "Dynamics of T- and B-Lymphocyte Turnover in a Natural Host of Simian Immunodeficiency Virus" @default.
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• W2112569051 doi "https://doi.org/10.1128/jvi.02197-07" @default.
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