FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112593942> ?p ?o ?g. }

• W2112593942 endingPage "199" @default.
• W2112593942 startingPage "195" @default.
• W2112593942 abstract "Although the mechanism involved in acute liver failure (ALF) has not yet been clarified, microcirculatory disturbance in the liver appears to play a pivotal role in the progression of this disease. To confirm the existence of hepatic hypoxic conditions, we evaluated the amounts of lactate dehydrogenase (LDH) in hepatocytes, since its production increases under low oxygen concentrations. Histological examination was performed in 7 patients with ALF. All 7 patients underwent a liver biopsy during the acute phase of ALF, and 4 of them underwent a second biopsy during the recovery phase. The obtained samples were immunohistochemically stained with anti-LDH5 and anti-CD-68 antibodies. As controls, we examined samples from patients with acute hepatitis, chronic hepatitis and liver cirrhosis. The production of LDH by hepatocytes and the number of CD-68 positive macrophages were markedly increased at the acute phase of ALF, and both of these effects abruptly decreased during the recovery phase. By contrast, most of the samples from the patients with chronic hepatitis and acute hepatitis showed slightly any increase in LDH staining. In cirrhotic patients, partially elevated LDH production was observed mainly around the central vein, but the staining intensity was less compared to that in ALF patients. Our findings indicate that hepatic hypoxic conditions exist in ALF at the acute phase and seem to closely correlate with macrophage overactivation in the liver. We speculate that microcirculatory disturbance may be a key process in the development and progression of ALF." @default.
• W2112593942 created "2016-06-24" @default.
• W2112593942 creator A5002003443 @default.
• W2112593942 creator A5006276959 @default.
• W2112593942 creator A5007692515 @default.
• W2112593942 creator A5012206634 @default.
• W2112593942 creator A5023885160 @default.
• W2112593942 creator A5031428988 @default.
• W2112593942 creator A5032236530 @default.
• W2112593942 creator A5068879641 @default.
• W2112593942 creator A5083352188 @default.
• W2112593942 date "2011-01-01" @default.
• W2112593942 modified "2023-09-27" @default.
• W2112593942 title "Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure" @default.
• W2112593942 cites W1970673999 @default.
• W2112593942 cites W1978714836 @default.
• W2112593942 cites W1981074654 @default.
• W2112593942 cites W2014634794 @default.
• W2112593942 cites W2017095731 @default.
• W2112593942 cites W2022445393 @default.
• W2112593942 cites W2027617641 @default.
• W2112593942 cites W2053469097 @default.
• W2112593942 cites W2061372968 @default.
• W2112593942 cites W2076576023 @default.
• W2112593942 cites W2082584138 @default.
• W2112593942 cites W2083266053 @default.
• W2112593942 cites W2112637709 @default.
• W2112593942 cites W2125703812 @default.
• W2112593942 cites W2131605289 @default.
• W2112593942 cites W2185956400 @default.
• W2112593942 cites W97023336 @default.
• W2112593942 doi "https://doi.org/10.3892/etm.2011.197" @default.
• W2112593942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3440653" @default.
• W2112593942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22977488" @default.
• W2112593942 hasPublicationYear "2011" @default.
• W2112593942 type Work @default.
• W2112593942 sameAs 2112593942 @default.
• W2112593942 citedByCount "47" @default.
• W2112593942 countsByYear W21125939422012 @default.
• W2112593942 countsByYear W21125939422013 @default.
• W2112593942 countsByYear W21125939422015 @default.
• W2112593942 countsByYear W21125939422016 @default.
• W2112593942 countsByYear W21125939422017 @default.
• W2112593942 countsByYear W21125939422018 @default.
• W2112593942 countsByYear W21125939422019 @default.
• W2112593942 countsByYear W21125939422020 @default.
• W2112593942 countsByYear W21125939422021 @default.
• W2112593942 countsByYear W21125939422022 @default.
• W2112593942 countsByYear W21125939422023 @default.
• W2112593942 crossrefType "journal-article" @default.
• W2112593942 hasAuthorship W2112593942A5002003443 @default.
• W2112593942 hasAuthorship W2112593942A5006276959 @default.
• W2112593942 hasAuthorship W2112593942A5007692515 @default.
• W2112593942 hasAuthorship W2112593942A5012206634 @default.
• W2112593942 hasAuthorship W2112593942A5023885160 @default.
• W2112593942 hasAuthorship W2112593942A5031428988 @default.
• W2112593942 hasAuthorship W2112593942A5032236530 @default.
• W2112593942 hasAuthorship W2112593942A5068879641 @default.
• W2112593942 hasAuthorship W2112593942A5083352188 @default.
• W2112593942 hasBestOaLocation W21125939421 @default.
• W2112593942 hasConcept C126322002 @default.
• W2112593942 hasConcept C142724271 @default.
• W2112593942 hasConcept C181199279 @default.
• W2112593942 hasConcept C2775934546 @default.
• W2112593942 hasConcept C2776029263 @default.
• W2112593942 hasConcept C2777075537 @default.
• W2112593942 hasConcept C2777214474 @default.
• W2112593942 hasConcept C2777318727 @default.
• W2112593942 hasConcept C2777766500 @default.
• W2112593942 hasConcept C2780325230 @default.
• W2112593942 hasConcept C55493867 @default.
• W2112593942 hasConcept C71924100 @default.
• W2112593942 hasConcept C86803240 @default.
• W2112593942 hasConcept C90924648 @default.
• W2112593942 hasConceptScore W2112593942C126322002 @default.
• W2112593942 hasConceptScore W2112593942C142724271 @default.
• W2112593942 hasConceptScore W2112593942C181199279 @default.
• W2112593942 hasConceptScore W2112593942C2775934546 @default.
• W2112593942 hasConceptScore W2112593942C2776029263 @default.
• W2112593942 hasConceptScore W2112593942C2777075537 @default.
• W2112593942 hasConceptScore W2112593942C2777214474 @default.
• W2112593942 hasConceptScore W2112593942C2777318727 @default.
• W2112593942 hasConceptScore W2112593942C2777766500 @default.
• W2112593942 hasConceptScore W2112593942C2780325230 @default.
• W2112593942 hasConceptScore W2112593942C55493867 @default.
• W2112593942 hasConceptScore W2112593942C71924100 @default.
• W2112593942 hasConceptScore W2112593942C86803240 @default.
• W2112593942 hasConceptScore W2112593942C90924648 @default.
• W2112593942 hasIssue "2" @default.
• W2112593942 hasLocation W21125939421 @default.
• W2112593942 hasLocation W21125939422 @default.
• W2112593942 hasLocation W21125939423 @default.
• W2112593942 hasLocation W21125939424 @default.
• W2112593942 hasOpenAccess W2112593942 @default.
• W2112593942 hasPrimaryLocation W21125939421 @default.
• W2112593942 hasRelatedWork W2077232892 @default.
• W2112593942 hasRelatedWork W2133277629 @default.
• W2112593942 hasRelatedWork W2382369664 @default.

• next