Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112606415> ?p ?o ?g. }
- W2112606415 endingPage "906" @default.
- W2112606415 startingPage "895" @default.
- W2112606415 abstract "Cyclin-dependent kinases (CDKs) are the key drivers of cell cycle progression and are often deregulated in cancer, therefore, targeting CDKs has long been pursued as a therapeutic strategy to tackle cancer. Unfortunately, however, none of the first-generation CDK inhibitors has yielded the expected efficacy to be successfully translated to the clinic mostly because, by targeting the very conserved kinase ATP-binding site resulted to be poorly specific and quite toxic.Here, the authors review recent approaches aimed at developing more specific CDK inhibitors mostly through the aid of computational drug design studies and report various small molecules and peptides, which resulted in promising CDK ATP-noncompetitive inhibitors.Despite few successes, these new approaches still need additional considerations to generate effective antitumoral agents. The authors discuss some of the hurdles to overcome for a successful clinical translation." @default.
- W2112606415 created "2016-06-24" @default.
- W2112606415 creator A5002523899 @default.
- W2112606415 creator A5024798356 @default.
- W2112606415 creator A5071039286 @default.
- W2112606415 creator A5074082081 @default.
- W2112606415 date "2013-06-04" @default.
- W2112606415 modified "2023-10-14" @default.
- W2112606415 title "ATP-noncompetitive CDK inhibitors for cancer therapy: an overview" @default.
- W2112606415 cites W1963676212 @default.
- W2112606415 cites W1964618225 @default.
- W2112606415 cites W1969345506 @default.
- W2112606415 cites W1970706880 @default.
- W2112606415 cites W1971140803 @default.
- W2112606415 cites W1978880815 @default.
- W2112606415 cites W1983987902 @default.
- W2112606415 cites W1990212809 @default.
- W2112606415 cites W1992272419 @default.
- W2112606415 cites W1994539742 @default.
- W2112606415 cites W1995038735 @default.
- W2112606415 cites W1996318954 @default.
- W2112606415 cites W1997073961 @default.
- W2112606415 cites W1999330214 @default.
- W2112606415 cites W2003570263 @default.
- W2112606415 cites W2005053674 @default.
- W2112606415 cites W2005982240 @default.
- W2112606415 cites W2007618242 @default.
- W2112606415 cites W2013253457 @default.
- W2112606415 cites W2013263858 @default.
- W2112606415 cites W2013557778 @default.
- W2112606415 cites W2018158228 @default.
- W2112606415 cites W2019127386 @default.
- W2112606415 cites W2021532899 @default.
- W2112606415 cites W2024121074 @default.
- W2112606415 cites W2025699039 @default.
- W2112606415 cites W2026166206 @default.
- W2112606415 cites W2027434096 @default.
- W2112606415 cites W2029048842 @default.
- W2112606415 cites W2030205108 @default.
- W2112606415 cites W2030461484 @default.
- W2112606415 cites W2030701381 @default.
- W2112606415 cites W2030986558 @default.
- W2112606415 cites W2035362119 @default.
- W2112606415 cites W2038143561 @default.
- W2112606415 cites W2040159113 @default.
- W2112606415 cites W2046024621 @default.
- W2112606415 cites W2046372158 @default.
- W2112606415 cites W2047628330 @default.
- W2112606415 cites W2050422354 @default.
- W2112606415 cites W2051208020 @default.
- W2112606415 cites W2051710717 @default.
- W2112606415 cites W2052115034 @default.
- W2112606415 cites W2052912081 @default.
- W2112606415 cites W2054345872 @default.
- W2112606415 cites W2057489420 @default.
- W2112606415 cites W2059671636 @default.
- W2112606415 cites W2062120857 @default.
- W2112606415 cites W2062604927 @default.
- W2112606415 cites W2064249962 @default.
- W2112606415 cites W2065617142 @default.
- W2112606415 cites W2066395260 @default.
- W2112606415 cites W2073341454 @default.
- W2112606415 cites W2074918415 @default.
- W2112606415 cites W2075770210 @default.
- W2112606415 cites W2078227844 @default.
- W2112606415 cites W2079398727 @default.
- W2112606415 cites W2080077392 @default.
- W2112606415 cites W2080570608 @default.
- W2112606415 cites W2084147994 @default.
- W2112606415 cites W2084404294 @default.
- W2112606415 cites W2084810833 @default.
- W2112606415 cites W2097836986 @default.
- W2112606415 cites W2105461540 @default.
- W2112606415 cites W2107448187 @default.
- W2112606415 cites W2111420633 @default.
- W2112606415 cites W2114381321 @default.
- W2112606415 cites W2121543046 @default.
- W2112606415 cites W2132066963 @default.
- W2112606415 cites W2132444412 @default.
- W2112606415 cites W2135129680 @default.
- W2112606415 cites W2137249911 @default.
- W2112606415 cites W2139753640 @default.
- W2112606415 cites W2142863884 @default.
- W2112606415 cites W2143162998 @default.
- W2112606415 cites W2148396794 @default.
- W2112606415 cites W2158110021 @default.
- W2112606415 cites W2161291887 @default.
- W2112606415 cites W2167398093 @default.
- W2112606415 cites W2199221141 @default.
- W2112606415 cites W2319461533 @default.
- W2112606415 cites W2322780159 @default.
- W2112606415 cites W2323748055 @default.
- W2112606415 cites W2476094235 @default.
- W2112606415 cites W4248107770 @default.
- W2112606415 cites W4295216797 @default.
- W2112606415 doi "https://doi.org/10.1517/13543784.2013.798641" @default.
- W2112606415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23735075" @default.
- W2112606415 hasPublicationYear "2013" @default.