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- W2112661837 abstract "The availability of a high quality draft sequence of the dog genome has changed the way geneticists study companion animals and how we are tackling the problem of finding genes that control complex traits. Of particular interest are genes controlling the morphologic differences that define different domestic dog breeds, genes regulating behavior, and those that increase disease susceptibility. Central to our ability to use the newly available resources is an understanding of dog breed structure. We present a detailed discussion of a new cluster analysis involving 132 American Kennel Club recognized breeds and varieties. The completion of this experiment has facilitated our efforts to map disease genes where the same pathologic disorder is present in a small number of breeds, but absent in the remaining majority. We will discuss the application of this approach to the problem of specific cancers occurring in small numbers of related breeds. Also important is an understanding of the strengths and limitations of the current molecular resources, and consideration of the traits that are likely to lend themselves to mapping using available approaches. We describe our recent efforts to localize genes important in controlling breed-defined fixed morphologic features. This study is built on the analysis of hundreds of dogs representing more than 75 breeds that were interrogated using the canine specific Affymetrix SNP chip that features 127,000 single nucleotide polymorphisms (Affymetrix, Santa Clara, CA). Analysis of these data for association with breed fixed traits identifies loci for a variety of morphologic features including, but not limited to, body size and skeletal shape. As an example of the power of this approach, we present new data for loci controlling leg morphology and coat type." @default.
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- W2112661837 date "2009-03-01" @default.
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- W2112661837 title "Noise reactivity in three breeds of herding dogs: What the crossroads of demography, ethology, and genetics can tell us" @default.
- W2112661837 doi "https://doi.org/10.1016/j.jveb.2008.09.024" @default.
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