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- W2112686543 endingPage "i72" @default.
- W2112686543 startingPage "i53" @default.
- W2112686543 abstract "Accumulating preclinical and clinical evidence suggests the possibility of neurotoxicity from neonatal exposure to general anaesthetics. Here, we review the weight of the evidence from both human and animal studies and discuss the putative mechanisms of injury and options for protective strategies. Our review identified 55 rodent studies, seven primate studies, and nine clinical studies of interest. While the preclinical data consistently demonstrate robust apoptosis in the nervous system after anaesthetic exposure, only a few studies have performed cognitive follow-up. Nonetheless, the emerging evidence that the primate brain is vulnerable to anaesthetic-induced apoptosis is of concern. The impact of surgery on anaesthetic-induced brain injury has not been adequately addressed yet. The clinical data, comprising largely retrospective cohort database analyses, are inconclusive, in part due to confounding variables inherent in these observational epidemiological approaches. This places even greater emphasis on prospective approaches to this problem, such as the ongoing GAS trial and PANDA study." @default.
- W2112686543 created "2016-06-24" @default.
- W2112686543 creator A5035895332 @default.
- W2112686543 creator A5036299315 @default.
- W2112686543 creator A5043856880 @default.
- W2112686543 creator A5052590910 @default.
- W2112686543 creator A5077788571 @default.
- W2112686543 date "2013-06-01" @default.
- W2112686543 modified "2023-10-18" @default.
- W2112686543 title "Impact of anaesthetics and surgery on neurodevelopment: an update" @default.
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