Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112714179> ?p ?o ?g. }
- W2112714179 endingPage "1473" @default.
- W2112714179 startingPage "1468" @default.
- W2112714179 abstract "Formaldehyde is ubiquitous in the environment. It is known to be a genotoxic substance. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved in formaldehyde-induced genotoxicity in human lung cancer cell lines A549. To test this hypothesis, we investigated the effects of antioxidant on formaldehyde-induced genotoxicity in A549 Cell Lines. Formaldehyde exposure caused induction of DNA-protein cross-links (DPCs). Curcumin is an important antioxidant. Formaldehyde significantly increased malondialdehyde (MDA) levels, and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity. In addition, the activation of NF-κB and AP-1 were induced by formaldehyde treatment. Pretreatment with curcumin counteracted formaldehyde-induced oxidative stress, ameliorated DPCs and attenuated activation of NF-κB and AP-1 in A549 Cell Lines. These results, taken together, suggest that formaldehyde induced genotoxicity through its ROS and lipid peroxidase activity and caused DPCs effects in A549 cells." @default.
- W2112714179 created "2016-06-24" @default.
- W2112714179 creator A5002832804 @default.
- W2112714179 creator A5009963713 @default.
- W2112714179 creator A5031810848 @default.
- W2112714179 creator A5034619258 @default.
- W2112714179 creator A5040573214 @default.
- W2112714179 creator A5059944329 @default.
- W2112714179 creator A5068855017 @default.
- W2112714179 date "2012-10-12" @default.
- W2112714179 modified "2023-10-13" @default.
- W2112714179 title "Protective effect of curcumin against formaldehyde-induced genotoxicity in A549 Cell Lines" @default.
- W2112714179 cites W1964902070 @default.
- W2112714179 cites W1966066591 @default.
- W2112714179 cites W1972033007 @default.
- W2112714179 cites W1974452557 @default.
- W2112714179 cites W1983903640 @default.
- W2112714179 cites W1984646350 @default.
- W2112714179 cites W1987158537 @default.
- W2112714179 cites W1988072297 @default.
- W2112714179 cites W1988732301 @default.
- W2112714179 cites W2000473996 @default.
- W2112714179 cites W2000682571 @default.
- W2112714179 cites W2009588836 @default.
- W2112714179 cites W2011844120 @default.
- W2112714179 cites W2012313272 @default.
- W2112714179 cites W2016729820 @default.
- W2112714179 cites W2023162539 @default.
- W2112714179 cites W2023187133 @default.
- W2112714179 cites W2024785511 @default.
- W2112714179 cites W2026825133 @default.
- W2112714179 cites W2031004545 @default.
- W2112714179 cites W2036224418 @default.
- W2112714179 cites W2036285113 @default.
- W2112714179 cites W2042314701 @default.
- W2112714179 cites W2045142972 @default.
- W2112714179 cites W2047236160 @default.
- W2112714179 cites W2052043292 @default.
- W2112714179 cites W2054808593 @default.
- W2112714179 cites W2055085312 @default.
- W2112714179 cites W2055815529 @default.
- W2112714179 cites W2056533846 @default.
- W2112714179 cites W2061514911 @default.
- W2112714179 cites W2066345544 @default.
- W2112714179 cites W2079178816 @default.
- W2112714179 cites W2084735541 @default.
- W2112714179 cites W2087737949 @default.
- W2112714179 cites W2097997319 @default.
- W2112714179 cites W2098553579 @default.
- W2112714179 cites W2100753182 @default.
- W2112714179 cites W2102851780 @default.
- W2112714179 cites W2105413614 @default.
- W2112714179 cites W2107359956 @default.
- W2112714179 cites W2109164958 @default.
- W2112714179 cites W2122572595 @default.
- W2112714179 cites W2140126848 @default.
- W2112714179 cites W2141985380 @default.
- W2112714179 cites W2146962477 @default.
- W2112714179 cites W2147890099 @default.
- W2112714179 cites W2148119611 @default.
- W2112714179 cites W2150247493 @default.
- W2112714179 cites W2151055722 @default.
- W2112714179 cites W2157524044 @default.
- W2112714179 cites W2164036989 @default.
- W2112714179 cites W2169141001 @default.
- W2112714179 doi "https://doi.org/10.1002/jat.2814" @default.
- W2112714179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23059809" @default.
- W2112714179 hasPublicationYear "2012" @default.
- W2112714179 type Work @default.
- W2112714179 sameAs 2112714179 @default.
- W2112714179 citedByCount "29" @default.
- W2112714179 countsByYear W21127141792013 @default.
- W2112714179 countsByYear W21127141792014 @default.
- W2112714179 countsByYear W21127141792015 @default.
- W2112714179 countsByYear W21127141792016 @default.
- W2112714179 countsByYear W21127141792017 @default.
- W2112714179 countsByYear W21127141792018 @default.
- W2112714179 countsByYear W21127141792019 @default.
- W2112714179 countsByYear W21127141792020 @default.
- W2112714179 countsByYear W21127141792021 @default.
- W2112714179 countsByYear W21127141792022 @default.
- W2112714179 countsByYear W21127141792023 @default.
- W2112714179 crossrefType "journal-article" @default.
- W2112714179 hasAuthorship W2112714179A5002832804 @default.
- W2112714179 hasAuthorship W2112714179A5009963713 @default.
- W2112714179 hasAuthorship W2112714179A5031810848 @default.
- W2112714179 hasAuthorship W2112714179A5034619258 @default.
- W2112714179 hasAuthorship W2112714179A5040573214 @default.
- W2112714179 hasAuthorship W2112714179A5059944329 @default.
- W2112714179 hasAuthorship W2112714179A5068855017 @default.
- W2112714179 hasConcept C143425029 @default.
- W2112714179 hasConcept C1491633281 @default.
- W2112714179 hasConcept C178790620 @default.
- W2112714179 hasConcept C181199279 @default.
- W2112714179 hasConcept C185592680 @default.
- W2112714179 hasConcept C2775838275 @default.
- W2112714179 hasConcept C2776151105 @default.
- W2112714179 hasConcept C2778004101 @default.