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• W2112730272 abstract "Under physiological conditions N-methyl-d-aspartate (NMDA) receptor activation requires coincidence of presynaptic glutamate release and postsynaptic depolarization due to the voltage-dependent block of these receptors by extracellular Mg 2+ . Therefore spontaneous neurotransmission in the absence of action potential firing is not expected to lead to significant NMDA receptor activation. Here we tested this assumption in layer IV neurons in neocortex at their resting membrane potential (approximately −67 mV). In long-duration stable recordings, we averaged a large number of miniature excitatory postsynaptic currents (mEPSCs, >100) before or after application of dl-2 amino 5-phosphonovaleric acid, a specific blocker of NMDA receptors. The difference between the two mEPSC waveforms showed that the NMDA current component comprises ∼20% of the charge transfer during an average mEPSC detected at rest. Importantly, the contribution of the NMDA component was markedly enhanced at membrane potentials expected for the depolarized up states (approximately −50 mV) that cortical neurons show during slow oscillations in vivo. In addition, partial block of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor component of the mEPSCs did not cause a significant reduction in the NMDA component, indicating that potential AMPA receptor-driven local depolarizations did not drive NMDA receptor activity at rest. Collectively these results indicate that NMDA receptors significantly contribute to signaling at rest in the absence of dendritic depolarizations or concomitant AMPA receptor activity." @default.
• W2112730272 created "2016-06-24" @default.
• W2112730272 creator A5006220862 @default.
• W2112730272 creator A5059395438 @default.
• W2112730272 date "2009-05-01" @default.
• W2112730272 modified "2023-09-23" @default.
• W2112730272 title "NMDA Receptor Activation by Spontaneous Glutamatergic Neurotransmission" @default.
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• W2112730272 doi "https://doi.org/10.1152/jn.90754.2008" @default.
• W2112730272 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2681428" @default.
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