Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112739745> ?p ?o ?g. }
- W2112739745 endingPage "1264" @default.
- W2112739745 startingPage "1251" @default.
- W2112739745 abstract "Abstract The growth of several mitotic mutants of Schizosaccharomyces pombe, including nuc2-663, is inhibited by the protease inhibitor N-Tosyl-L-Phenylalanine Chloromethyl Ketone (TPCK). Because nuc2+ encodes a presumptive component of the Anaphase Promoting Complex, which is required for the ubiquitin-dependent proteolysis of certain proteins during exit from mitosis, we have used sensitivity to TPCK as a criterion by which to search for novel S. pombe mutants defective in the anaphase-promoting pathway. In a genetic screen for temperature-sensitive mitotic mutants that were also sensitive to TPCK at a permissive temperature, we isolated three tsm (TPCK-sensitive mitotic) strains. Two of these are alleles of cut1+, but tsm1-512 maps to a novel genetic location. The tsm1-512 mutation leads to delayed nuclear division at restrictive temperatures, apparently as a result of an impaired ability to form a metaphase spindle. After shift of early G2 cells to 36°, tsm1-512 arrests transiently in the second mitotic division and then exits mitosis, as judged by spindle elongation and septation. The chromosomes, however, often fail to segregate properly. Genetic interactions between tsm1-512 and components of the anaphase proteolytic pathway suggest a functional involvement of the Tsm1 protein in this pathway." @default.
- W2112739745 created "2016-06-24" @default.
- W2112739745 creator A5043243542 @default.
- W2112739745 creator A5048073250 @default.
- W2112739745 creator A5083476111 @default.
- W2112739745 date "1998-07-01" @default.
- W2112739745 modified "2023-10-01" @default.
- W2112739745 title "A Screen for Genes Involved in the Anaphase Proteolytic Pathway Identifies tsm1+, a Novel Schizosaccharomyces pombe Gene Important for Microtubule Integrity" @default.
- W2112739745 cites W149322370 @default.
- W2112739745 cites W1508414663 @default.
- W2112739745 cites W1518640128 @default.
- W2112739745 cites W1553028151 @default.
- W2112739745 cites W1562654885 @default.
- W2112739745 cites W163073416 @default.
- W2112739745 cites W1839021542 @default.
- W2112739745 cites W1879884822 @default.
- W2112739745 cites W1894461767 @default.
- W2112739745 cites W1934183749 @default.
- W2112739745 cites W1965836933 @default.
- W2112739745 cites W1971208791 @default.
- W2112739745 cites W1973622904 @default.
- W2112739745 cites W1975462016 @default.
- W2112739745 cites W1977034044 @default.
- W2112739745 cites W1981772689 @default.
- W2112739745 cites W1982515699 @default.
- W2112739745 cites W1990634825 @default.
- W2112739745 cites W1991101546 @default.
- W2112739745 cites W1995653496 @default.
- W2112739745 cites W1996604319 @default.
- W2112739745 cites W2001139153 @default.
- W2112739745 cites W2001728435 @default.
- W2112739745 cites W2003217557 @default.
- W2112739745 cites W2003577370 @default.
- W2112739745 cites W2005717642 @default.
- W2112739745 cites W2008517878 @default.
- W2112739745 cites W2009073107 @default.
- W2112739745 cites W2010015418 @default.
- W2112739745 cites W2015997780 @default.
- W2112739745 cites W2019068828 @default.
- W2112739745 cites W2022174848 @default.
- W2112739745 cites W2030082109 @default.
- W2112739745 cites W2036356274 @default.
- W2112739745 cites W2039839254 @default.
- W2112739745 cites W2046897840 @default.
- W2112739745 cites W2047156618 @default.
- W2112739745 cites W2047344741 @default.
- W2112739745 cites W2048947506 @default.
- W2112739745 cites W2064331227 @default.
- W2112739745 cites W2065445924 @default.
- W2112739745 cites W2069063162 @default.
- W2112739745 cites W2071941030 @default.
- W2112739745 cites W2084343743 @default.
- W2112739745 cites W2084901114 @default.
- W2112739745 cites W2085962516 @default.
- W2112739745 cites W2086192909 @default.
- W2112739745 cites W2089577641 @default.
- W2112739745 cites W2096268139 @default.
- W2112739745 cites W2096864462 @default.
- W2112739745 cites W2106431538 @default.
- W2112739745 cites W2106869142 @default.
- W2112739745 cites W2123869586 @default.
- W2112739745 cites W2129646494 @default.
- W2112739745 cites W2129771792 @default.
- W2112739745 cites W2146084258 @default.
- W2112739745 cites W2150453547 @default.
- W2112739745 cites W2169733104 @default.
- W2112739745 cites W2311110868 @default.
- W2112739745 cites W2485721103 @default.
- W2112739745 cites W4253376607 @default.
- W2112739745 cites W95050424 @default.
- W2112739745 cites W990069178 @default.
- W2112739745 cites W1994623104 @default.
- W2112739745 doi "https://doi.org/10.1093/genetics/149.3.1251" @default.
- W2112739745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460230" @default.
- W2112739745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9649518" @default.
- W2112739745 hasPublicationYear "1998" @default.
- W2112739745 type Work @default.
- W2112739745 sameAs 2112739745 @default.
- W2112739745 citedByCount "9" @default.
- W2112739745 crossrefType "journal-article" @default.
- W2112739745 hasAuthorship W2112739745A5043243542 @default.
- W2112739745 hasAuthorship W2112739745A5048073250 @default.
- W2112739745 hasAuthorship W2112739745A5083476111 @default.
- W2112739745 hasBestOaLocation W21127397451 @default.
- W2112739745 hasConcept C104317684 @default.
- W2112739745 hasConcept C143065580 @default.
- W2112739745 hasConcept C1491633281 @default.
- W2112739745 hasConcept C207177822 @default.
- W2112739745 hasConcept C2776519988 @default.
- W2112739745 hasConcept C2778354886 @default.
- W2112739745 hasConcept C2779429346 @default.
- W2112739745 hasConcept C30481170 @default.
- W2112739745 hasConcept C45472230 @default.
- W2112739745 hasConcept C47432576 @default.
- W2112739745 hasConcept C53420372 @default.
- W2112739745 hasConcept C54355233 @default.
- W2112739745 hasConcept C6391034 @default.
- W2112739745 hasConcept C70278784 @default.