Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112748663> ?p ?o ?g. }
- W2112748663 endingPage "144" @default.
- W2112748663 startingPage "136" @default.
- W2112748663 abstract "Coagulation factor XII is involved in thrombus formation and therefore may play a role in the etiology of thrombotic disorders. A common variant in the factor XII (F12) gene (−4C>T, rs1801020) results in decreased plasma levels of this coagulation factor. The existence of associations between low factor XII levels or F12 variants and thrombotic outcomes has been debated for more than a decade. The authors conducted a review and meta-analysis to evaluate the evidence for an association between F12 −4C>T and 2 common thrombotic outcomes: venous thromboembolism and myocardial infarction, which are hypothesized to share some etiologic pathways. MEDLINE, EMBASE, and HuGE Navigator were searched through July 2009 to identify relevant epidemiologic studies, and data were summarized using random-effects meta-analysis. Sixteen candidate gene studies (4,386 cases, 40,089 controls) were analyzed. None of the investigated contrasts reached statistical significance at P < 0.05, apart from a very weak association with myocardial infarction for the TT + CT versus CC contrast (odds ratio = 1.13, 95% confidence interval: 1.00, 1.27). Overall, based on the synthesis of observational studies, the evidence for an association between F12 −4C>T and venous thromboembolism and myocardial infarction is weak." @default.
- W2112748663 created "2016-06-24" @default.
- W2112748663 creator A5070950600 @default.
- W2112748663 creator A5075380485 @default.
- W2112748663 creator A5078127601 @default.
- W2112748663 creator A5085775742 @default.
- W2112748663 date "2010-11-16" @default.
- W2112748663 modified "2023-10-05" @default.
- W2112748663 title "The Factor XII −4C>T Variant and Risk of Common Thrombotic Disorders: A HuGE Review and Meta-Analysis of Evidence From Observational Studies" @default.
- W2112748663 cites W1590740620 @default.
- W2112748663 cites W170029154 @default.
- W2112748663 cites W1825093578 @default.
- W2112748663 cites W1962947285 @default.
- W2112748663 cites W1969881683 @default.
- W2112748663 cites W1972669010 @default.
- W2112748663 cites W1973798273 @default.
- W2112748663 cites W1986661081 @default.
- W2112748663 cites W1997454349 @default.
- W2112748663 cites W1998712442 @default.
- W2112748663 cites W1999608231 @default.
- W2112748663 cites W2000267168 @default.
- W2112748663 cites W2002680697 @default.
- W2112748663 cites W2003009521 @default.
- W2112748663 cites W2006040901 @default.
- W2112748663 cites W2008874438 @default.
- W2112748663 cites W2018129107 @default.
- W2112748663 cites W2021837301 @default.
- W2112748663 cites W2022111125 @default.
- W2112748663 cites W2027228229 @default.
- W2112748663 cites W2036198235 @default.
- W2112748663 cites W2036655503 @default.
- W2112748663 cites W2037957399 @default.
- W2112748663 cites W2038129075 @default.
- W2112748663 cites W2049971614 @default.
- W2112748663 cites W2053264658 @default.
- W2112748663 cites W2054153086 @default.
- W2112748663 cites W2057802602 @default.
- W2112748663 cites W2061616966 @default.
- W2112748663 cites W2066816352 @default.
- W2112748663 cites W2067813060 @default.
- W2112748663 cites W2077119068 @default.
- W2112748663 cites W2078293147 @default.
- W2112748663 cites W2079711415 @default.
- W2112748663 cites W2081472075 @default.
- W2112748663 cites W2085171382 @default.
- W2112748663 cites W2088722089 @default.
- W2112748663 cites W2101902212 @default.
- W2112748663 cites W2105736694 @default.
- W2112748663 cites W2109139065 @default.
- W2112748663 cites W2113525532 @default.
- W2112748663 cites W2120451046 @default.
- W2112748663 cites W2122106194 @default.
- W2112748663 cites W2125474642 @default.
- W2112748663 cites W2126718294 @default.
- W2112748663 cites W2128201302 @default.
- W2112748663 cites W2129792561 @default.
- W2112748663 cites W2133762037 @default.
- W2112748663 cites W2141364619 @default.
- W2112748663 cites W2148817003 @default.
- W2112748663 cites W2153103369 @default.
- W2112748663 cites W2153306700 @default.
- W2112748663 cites W2155806032 @default.
- W2112748663 cites W2157823046 @default.
- W2112748663 cites W2162088713 @default.
- W2112748663 cites W2169294950 @default.
- W2112748663 cites W2171079026 @default.
- W2112748663 cites W2228741158 @default.
- W2112748663 cites W2415189724 @default.
- W2112748663 cites W42189419 @default.
- W2112748663 cites W4322696781 @default.
- W2112748663 doi "https://doi.org/10.1093/aje/kwq349" @default.
- W2112748663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21071604" @default.
- W2112748663 hasPublicationYear "2010" @default.
- W2112748663 type Work @default.
- W2112748663 sameAs 2112748663 @default.
- W2112748663 citedByCount "23" @default.
- W2112748663 countsByYear W21127486632012 @default.
- W2112748663 countsByYear W21127486632013 @default.
- W2112748663 countsByYear W21127486632014 @default.
- W2112748663 countsByYear W21127486632015 @default.
- W2112748663 countsByYear W21127486632016 @default.
- W2112748663 countsByYear W21127486632019 @default.
- W2112748663 countsByYear W21127486632021 @default.
- W2112748663 countsByYear W21127486632022 @default.
- W2112748663 crossrefType "journal-article" @default.
- W2112748663 hasAuthorship W2112748663A5070950600 @default.
- W2112748663 hasAuthorship W2112748663A5075380485 @default.
- W2112748663 hasAuthorship W2112748663A5078127601 @default.
- W2112748663 hasAuthorship W2112748663A5085775742 @default.
- W2112748663 hasBestOaLocation W21127486631 @default.
- W2112748663 hasConcept C126322002 @default.
- W2112748663 hasConcept C137627325 @default.
- W2112748663 hasConcept C156957248 @default.
- W2112748663 hasConcept C164705383 @default.
- W2112748663 hasConcept C23131810 @default.
- W2112748663 hasConcept C2781362458 @default.
- W2112748663 hasConcept C44249647 @default.
- W2112748663 hasConcept C500558357 @default.