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- W2112752425 abstract "A small (30 g) mouse is capable of mass-specific rates of oxygen consumption that are nearly ten times greater than those of a 300-kg steer. This review addresses a simple question: What are the physiological and structural bases for these large differences? I first consider how maximal rates of oxygen consumption scale with body size and then consider the processes in the muscle that consume ATP and set the demand for oxygen. Finally, I consider the role of the mitochondria of muscle, the organelles where the oxygen is consumed and ATP is produced, in setting this upper limit. The review by Ewald Weibel that follows considers the structures involved in moving the oxygen from the environment to the mitochondria. This review and that of Weibel address the general question of whether or not there is a !!latch between structures and their function under rate-limiting conditions of V °2,,,,' The tenfold differences in maximal rates of oxygen flow per unit mass that occur with body size provide an excellent opportunity to test for this match (24)." @default.
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- W2112752425 date "1987-03-01" @default.
- W2112752425 modified "2023-10-15" @default.
- W2112752425 title "Structural and Functional Limits to Oxidative Metabolism: Insights from Scaling" @default.
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- W2112752425 doi "https://doi.org/10.1146/annurev.ph.49.030187.001031" @default.
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