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- W2112779931 abstract "Porogen leaching is a widely used and simple technique for the creation of porous scaffolds in tissue engineering. Sodium chloride (NaCl) is the most commonly used porogen, but the current grinding and sieving methods generate salt particles with huge size variations and cannot generate porogens in the submicron size range. We have developed a facile method based on the principles of crystallization to precisely control salt crystal sizes down to a few microns within a narrow size distribution. The resulting NaCl crystal size could be controlled through the solution concentration, crystallization temperature, and crystallization time. A reduction in solution temperature, longer crystallization times, and an increase in salt concentration resulted in an increase in NaCl crystal sizes due to the lowered solubility of the salt solution. The nucleation and crystallization technique provides superior control over the resulting NaCl size distribution (13.78 ± 1.18 μm), whereas the traditional grinding and sieving methods produced NaCl porogens 13.89 ± 12.49 μm in size. The resulting NaCl porogens were used to fabricate scaffolds with increased interconnectivity, porous microchanneled scaffolds, and multiphasic vascular grafts. This new generation of salt porogen provides great freedom in designing versatile scaffolds for various tissue-engineering applications." @default.
- W2112779931 created "2016-06-24" @default.
- W2112779931 creator A5024870677 @default.
- W2112779931 creator A5026542289 @default.
- W2112779931 creator A5053774438 @default.
- W2112779931 creator A5066683037 @default.
- W2112779931 creator A5086125276 @default.
- W2112779931 date "2011-09-01" @default.
- W2112779931 modified "2023-10-02" @default.
- W2112779931 title "A new generation of sodium chloride porogen for tissue engineering" @default.
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- W2112779931 doi "https://doi.org/10.1002/bab.44" @default.
- W2112779931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21995536" @default.
- W2112779931 hasPublicationYear "2011" @default.
- W2112779931 type Work @default.