Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112784003> ?p ?o ?g. }
- W2112784003 endingPage "5890" @default.
- W2112784003 startingPage "5886" @default.
- W2112784003 abstract "In order to gain greater understanding of the mechanisms underlying the effect of epigallocatechin-3-gallate (EGCG) on DNA methylation and its chemopreventative action in oral squamous cell carcinoma (OSCC), a genome‑wide methylation and mRNA expression screen was performed in the CAL‑27 cell line with and without EGCG (100 µM) treatment. A total of 761 differentially methylated gene loci were identified following treatment with EGCG. Comparison of gene expression profiling in OSCC samples revealed 184 transcripts with a significant difference (P<0.05) and a fold change difference >2 compared with controls. Gene ontology analysis of differentially methylated loci and functional annotation of the differentially expressed genes indicated that the main pathways involved were metabolic, mitogen‑activated protein kinase (MAPK), wnt, and cell cycle pathways. In conclusion, the present study indicates that EGCG can affect the methylation status and gene expression in the CAL‑27 cell line. Additionally, the changes in several important signaling pathways may reveal the antitumor mechanism of EGCG." @default.
- W2112784003 created "2016-06-24" @default.
- W2112784003 creator A5008123764 @default.
- W2112784003 creator A5020302124 @default.
- W2112784003 creator A5045330493 @default.
- W2112784003 creator A5075426616 @default.
- W2112784003 date "2015-07-27" @default.
- W2112784003 modified "2023-10-14" @default.
- W2112784003 title "A genome-wide study of DNA methylation modified by epigallocatechin-3-gallate in the CAL-27 cell line" @default.
- W2112784003 cites W1515399093 @default.
- W2112784003 cites W1518909941 @default.
- W2112784003 cites W1808332509 @default.
- W2112784003 cites W1946637239 @default.
- W2112784003 cites W1973244778 @default.
- W2112784003 cites W1976013072 @default.
- W2112784003 cites W1976882367 @default.
- W2112784003 cites W1980349375 @default.
- W2112784003 cites W1985245844 @default.
- W2112784003 cites W1997342684 @default.
- W2112784003 cites W1997815516 @default.
- W2112784003 cites W2020830322 @default.
- W2112784003 cites W2023036413 @default.
- W2112784003 cites W2030371171 @default.
- W2112784003 cites W2031940984 @default.
- W2112784003 cites W2049767158 @default.
- W2112784003 cites W2065207838 @default.
- W2112784003 cites W2065442503 @default.
- W2112784003 cites W2067266295 @default.
- W2112784003 cites W2068255220 @default.
- W2112784003 cites W2070785261 @default.
- W2112784003 cites W2082419651 @default.
- W2112784003 cites W2092330761 @default.
- W2112784003 cites W2108024349 @default.
- W2112784003 cites W2124510560 @default.
- W2112784003 cites W2129262211 @default.
- W2112784003 cites W2135642745 @default.
- W2112784003 cites W2136492640 @default.
- W2112784003 cites W2158380218 @default.
- W2112784003 doi "https://doi.org/10.3892/mmr.2015.4118" @default.
- W2112784003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26239270" @default.
- W2112784003 hasPublicationYear "2015" @default.
- W2112784003 type Work @default.
- W2112784003 sameAs 2112784003 @default.
- W2112784003 citedByCount "13" @default.
- W2112784003 countsByYear W21127840032016 @default.
- W2112784003 countsByYear W21127840032017 @default.
- W2112784003 countsByYear W21127840032018 @default.
- W2112784003 countsByYear W21127840032019 @default.
- W2112784003 countsByYear W21127840032020 @default.
- W2112784003 countsByYear W21127840032022 @default.
- W2112784003 crossrefType "journal-article" @default.
- W2112784003 hasAuthorship W2112784003A5008123764 @default.
- W2112784003 hasAuthorship W2112784003A5020302124 @default.
- W2112784003 hasAuthorship W2112784003A5045330493 @default.
- W2112784003 hasAuthorship W2112784003A5075426616 @default.
- W2112784003 hasBestOaLocation W21127840031 @default.
- W2112784003 hasConcept C104317684 @default.
- W2112784003 hasConcept C137620995 @default.
- W2112784003 hasConcept C150194340 @default.
- W2112784003 hasConcept C153911025 @default.
- W2112784003 hasConcept C18431079 @default.
- W2112784003 hasConcept C190727270 @default.
- W2112784003 hasConcept C2781018059 @default.
- W2112784003 hasConcept C29537977 @default.
- W2112784003 hasConcept C33288867 @default.
- W2112784003 hasConcept C54355233 @default.
- W2112784003 hasConcept C57074206 @default.
- W2112784003 hasConcept C62478195 @default.
- W2112784003 hasConcept C86803240 @default.
- W2112784003 hasConceptScore W2112784003C104317684 @default.
- W2112784003 hasConceptScore W2112784003C137620995 @default.
- W2112784003 hasConceptScore W2112784003C150194340 @default.
- W2112784003 hasConceptScore W2112784003C153911025 @default.
- W2112784003 hasConceptScore W2112784003C18431079 @default.
- W2112784003 hasConceptScore W2112784003C190727270 @default.
- W2112784003 hasConceptScore W2112784003C2781018059 @default.
- W2112784003 hasConceptScore W2112784003C29537977 @default.
- W2112784003 hasConceptScore W2112784003C33288867 @default.
- W2112784003 hasConceptScore W2112784003C54355233 @default.
- W2112784003 hasConceptScore W2112784003C57074206 @default.
- W2112784003 hasConceptScore W2112784003C62478195 @default.
- W2112784003 hasConceptScore W2112784003C86803240 @default.
- W2112784003 hasIssue "4" @default.
- W2112784003 hasLocation W21127840031 @default.
- W2112784003 hasLocation W21127840032 @default.
- W2112784003 hasOpenAccess W2112784003 @default.
- W2112784003 hasPrimaryLocation W21127840031 @default.
- W2112784003 hasRelatedWork W1969774671 @default.
- W2112784003 hasRelatedWork W2002128513 @default.
- W2112784003 hasRelatedWork W2009966535 @default.
- W2112784003 hasRelatedWork W2056743477 @default.
- W2112784003 hasRelatedWork W2078926220 @default.
- W2112784003 hasRelatedWork W2320606495 @default.
- W2112784003 hasRelatedWork W2982306571 @default.
- W2112784003 hasRelatedWork W3122166869 @default.
- W2112784003 hasRelatedWork W3126383472 @default.
- W2112784003 hasRelatedWork W4283027398 @default.
- W2112784003 hasVolume "12" @default.