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- W2112792380 abstract "We demonstrate that JNK responds to substrate stiffness and regulates AJ formation in epithelial cells in 2D cultures and in 3D tissues in vitro and in vivo. Rigid substrates led to JNK activation and AJ disassembly, while soft matrices suppressed JNK activity leading to AJ formation. Expression of constitutively active JNK (MKK7-JNK1) induced AJ dissolution even on soft substrates, while JNK knockdown (shJNK) induced AJ formation even on hard substrates. In human epidermis, basal cells expressed phosphorylated (p)-JNK but lacked AJ, while suprabasal keratinocytes contained strong AJ but lacked p-JNK. AJ formation was significantly impaired even in the upper suprabasal layers of bioengineered epidermis when prepared with stiffer scaffold or MKK7-JNK1 expressing keratinocytes. In contrast, shJNK1 or shJNK2 epidermis exhibited strong AJ even in the basal layer. The results with bioengineered epidermis were in full agreement with the epidermis of jnk1−/− or jnk2−/− mice. In conclusion, we propose that JNK mediates the effects of substrate stiffness on AJ formation in 2D and 3D context in vitro as well as in vivo." @default.
- W2112792380 created "2016-06-24" @default.
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- W2112792380 date "2013-01-01" @default.
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- W2112792380 title "Compliance-induced adherens junction formation in epithelial cells and tissues is regulated by JNK" @default.
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- W2112792380 doi "https://doi.org/10.1242/jcs.122903" @default.
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