Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112794045> ?p ?o ?g. }
- W2112794045 endingPage "1397" @default.
- W2112794045 startingPage "1388" @default.
- W2112794045 abstract "Neoplastic progression is an evolutionary process driven by the generation of clonal diversity and natural selection on that diversity within a neoplasm. We hypothesized that clonal diversity is associated with risk of progression to cancer. We obtained molecular data from a cohort of 239 participants with Barrett's esophagus, including microsatellite shifts and loss of heterozygosity, DNA content tetraploidy and aneuploidy, methylation, and sequence mutations. Using these data, we tested all major diversity measurement methods, including genetic divergence and entropy-based measures, to determine which measures are correlated with risk of progression to esophageal adenocarcinoma. We also tested whether the use of different sets of loci and alterations to define clones (e.g., selectively advantageous versus evolutionarily neutral) improved the predictive value of the diversity indices. All diversity measures were strong and highly significant predictors of progression (Cox proportional hazards model, P < 0.001). The type of alterations evaluated had little effect on the predictive value of most of the diversity measures. In summary, diversity measures are robust predictors of progression to cancer in this cohort." @default.
- W2112794045 created "2016-06-24" @default.
- W2112794045 creator A5011306393 @default.
- W2112794045 creator A5020071542 @default.
- W2112794045 creator A5025406097 @default.
- W2112794045 creator A5044226852 @default.
- W2112794045 creator A5057244007 @default.
- W2112794045 creator A5062132898 @default.
- W2112794045 creator A5083729859 @default.
- W2112794045 date "2010-11-01" @default.
- W2112794045 modified "2023-09-30" @default.
- W2112794045 title "A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma" @default.
- W2112794045 cites W1524908669 @default.
- W2112794045 cites W154552301 @default.
- W2112794045 cites W1573413333 @default.
- W2112794045 cites W1758349423 @default.
- W2112794045 cites W1856235061 @default.
- W2112794045 cites W1863193264 @default.
- W2112794045 cites W1967304777 @default.
- W2112794045 cites W1973568247 @default.
- W2112794045 cites W1978499139 @default.
- W2112794045 cites W2005422079 @default.
- W2112794045 cites W2022825068 @default.
- W2112794045 cites W2031330193 @default.
- W2112794045 cites W2046133119 @default.
- W2112794045 cites W2048143418 @default.
- W2112794045 cites W2062556935 @default.
- W2112794045 cites W2067795112 @default.
- W2112794045 cites W2070142954 @default.
- W2112794045 cites W2078134864 @default.
- W2112794045 cites W2084819007 @default.
- W2112794045 cites W2086698289 @default.
- W2112794045 cites W2106088192 @default.
- W2112794045 cites W2107812500 @default.
- W2112794045 cites W2117870131 @default.
- W2112794045 cites W2120474334 @default.
- W2112794045 cites W2122576282 @default.
- W2112794045 cites W2123558100 @default.
- W2112794045 cites W2128397737 @default.
- W2112794045 cites W2131301097 @default.
- W2112794045 cites W2132696570 @default.
- W2112794045 cites W2134351926 @default.
- W2112794045 cites W2135160082 @default.
- W2112794045 cites W2149552304 @default.
- W2112794045 cites W2160076878 @default.
- W2112794045 cites W2160411950 @default.
- W2112794045 cites W2315914439 @default.
- W2112794045 cites W2320017053 @default.
- W2112794045 doi "https://doi.org/10.1158/1940-6207.capr-10-0108" @default.
- W2112794045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3004782" @default.
- W2112794045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20947487" @default.
- W2112794045 hasPublicationYear "2010" @default.
- W2112794045 type Work @default.
- W2112794045 sameAs 2112794045 @default.
- W2112794045 citedByCount "141" @default.
- W2112794045 countsByYear W21127940452012 @default.
- W2112794045 countsByYear W21127940452013 @default.
- W2112794045 countsByYear W21127940452014 @default.
- W2112794045 countsByYear W21127940452015 @default.
- W2112794045 countsByYear W21127940452016 @default.
- W2112794045 countsByYear W21127940452017 @default.
- W2112794045 countsByYear W21127940452018 @default.
- W2112794045 countsByYear W21127940452019 @default.
- W2112794045 countsByYear W21127940452020 @default.
- W2112794045 countsByYear W21127940452021 @default.
- W2112794045 countsByYear W21127940452022 @default.
- W2112794045 countsByYear W21127940452023 @default.
- W2112794045 crossrefType "journal-article" @default.
- W2112794045 hasAuthorship W2112794045A5011306393 @default.
- W2112794045 hasAuthorship W2112794045A5020071542 @default.
- W2112794045 hasAuthorship W2112794045A5025406097 @default.
- W2112794045 hasAuthorship W2112794045A5044226852 @default.
- W2112794045 hasAuthorship W2112794045A5057244007 @default.
- W2112794045 hasAuthorship W2112794045A5062132898 @default.
- W2112794045 hasAuthorship W2112794045A5083729859 @default.
- W2112794045 hasBestOaLocation W21127940451 @default.
- W2112794045 hasConcept C104317684 @default.
- W2112794045 hasConcept C121608353 @default.
- W2112794045 hasConcept C126322002 @default.
- W2112794045 hasConcept C143589142 @default.
- W2112794045 hasConcept C143998085 @default.
- W2112794045 hasConcept C180754005 @default.
- W2112794045 hasConcept C2778589982 @default.
- W2112794045 hasConcept C2781182431 @default.
- W2112794045 hasConcept C2908647359 @default.
- W2112794045 hasConcept C54355233 @default.
- W2112794045 hasConcept C71924100 @default.
- W2112794045 hasConcept C72563966 @default.
- W2112794045 hasConcept C81977670 @default.
- W2112794045 hasConcept C86803240 @default.
- W2112794045 hasConcept C99454951 @default.
- W2112794045 hasConceptScore W2112794045C104317684 @default.
- W2112794045 hasConceptScore W2112794045C121608353 @default.
- W2112794045 hasConceptScore W2112794045C126322002 @default.
- W2112794045 hasConceptScore W2112794045C143589142 @default.
- W2112794045 hasConceptScore W2112794045C143998085 @default.
- W2112794045 hasConceptScore W2112794045C180754005 @default.
- W2112794045 hasConceptScore W2112794045C2778589982 @default.