FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112804589> ?p ?o ?g. }

• W2112804589 endingPage "629" @default.
• W2112804589 startingPage "618" @default.
• W2112804589 abstract "Abstract Reactive astrogliosis is a prominent neuropathologic feature of manganism, a neurodegenerative disorder caused by excessive accumulation of manganese (Mn) in the basal ganglia. Activation of astrocytes has been linked to neuronal injury in manganism resulting from overproduction of inflammatory mediators, including tumor necrosis factor‐α (TNFα), interferon‐γ (IFNγ), interleukin‐1β (IL‐1β), and nitric oxide (NO), but the signaling mechanisms by which Mn regulates these factors remain poorly understood. We previously reported that Mn enhances production of NO in activated astrocytes that promotes apoptosis in cocultured neuronal cells by a mechanism involving the transcription factor nuclear factor‐κB (NF‐κB) (Liu et al., 2005 ). Because NF‐κB‐dependent expression of inducible nitric oxide synthase (NOS2) can be antagonized by the nuclear orphan receptor peroxisome proliferator‐activated receptor‐γ (PPARγ), we postulated that a novel agonist of this receptor, 1,1‐bis(3′‐indolyl)‐1‐(p‐trifluoromethylphenyl)methane (cDIM1), would suppress expression of NOS2 in astrocytes and protect cocultured neuronal cells from apoptosis. Submicromolar concentrations of cDIM1 potently suppressed production of NO and expression of NOS2 in cultured astrocytes exposed to Mn and IFNγ/TNFα and prevented apoptosis in cocultures of differentiated PC12 cells, but this neuroprotective effect was lost in the absence of astrocytes. By using fluorescence reporter and chromatin immunoprecipitation (ChIP) assays, we found that cDIM1 prevented activation of NF‐κB in astrocytes by a mechanism involving stabilization of the nuclear corepressor 2 (NCoR2) on the proximal NF‐κB binding site of the NOS2 promoter. These data suggest that PPARγ may be an effective target for limiting inflammatory activation of astrocytes during neurologic injury. © 2007 Wiley‐Liss, Inc." @default.
• W2112804589 created "2016-06-24" @default.
• W2112804589 creator A5002274261 @default.
• W2112804589 creator A5022252180 @default.
• W2112804589 creator A5035746727 @default.
• W2112804589 creator A5036575223 @default.
• W2112804589 creator A5047611204 @default.
• W2112804589 creator A5061617494 @default.
• W2112804589 creator A5062800007 @default.
• W2112804589 date "2007-11-26" @default.
• W2112804589 modified "2023-10-18" @default.
• W2112804589 title "The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells" @default.
• W2112804589 cites W1530199299 @default.
• W2112804589 cites W1535444616 @default.
• W2112804589 cites W1539688129 @default.
• W2112804589 cites W1558213119 @default.
• W2112804589 cites W1591881963 @default.
• W2112804589 cites W1713124107 @default.
• W2112804589 cites W1911775654 @default.
• W2112804589 cites W1980039414 @default.
• W2112804589 cites W1982963480 @default.
• W2112804589 cites W1985487558 @default.
• W2112804589 cites W1997388541 @default.
• W2112804589 cites W1997536241 @default.
• W2112804589 cites W1998296450 @default.
• W2112804589 cites W2002562482 @default.
• W2112804589 cites W2007456673 @default.
• W2112804589 cites W2014515679 @default.
• W2112804589 cites W2018649598 @default.
• W2112804589 cites W2025678369 @default.
• W2112804589 cites W2029177106 @default.
• W2112804589 cites W2031272027 @default.
• W2112804589 cites W2035162752 @default.
• W2112804589 cites W2047852384 @default.
• W2112804589 cites W2062084653 @default.
• W2112804589 cites W2073028327 @default.
• W2112804589 cites W2082431283 @default.
• W2112804589 cites W2090409342 @default.
• W2112804589 cites W2095080894 @default.
• W2112804589 cites W2101706357 @default.
• W2112804589 cites W2104841128 @default.
• W2112804589 cites W2115887372 @default.
• W2112804589 cites W2121068398 @default.
• W2112804589 cites W2124080310 @default.
• W2112804589 cites W2125407940 @default.
• W2112804589 cites W2128708131 @default.
• W2112804589 cites W2136784046 @default.
• W2112804589 cites W2145373251 @default.
• W2112804589 cites W2146547874 @default.
• W2112804589 cites W2146720128 @default.
• W2112804589 cites W2147944081 @default.
• W2112804589 cites W2148036798 @default.
• W2112804589 cites W2154732083 @default.
• W2112804589 cites W2169889836 @default.
• W2112804589 doi "https://doi.org/10.1002/jnr.21524" @default.
• W2112804589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18041089" @default.
• W2112804589 hasPublicationYear "2007" @default.
• W2112804589 type Work @default.
• W2112804589 sameAs 2112804589 @default.
• W2112804589 citedByCount "22" @default.
• W2112804589 countsByYear W21128045892012 @default.
• W2112804589 countsByYear W21128045892013 @default.
• W2112804589 countsByYear W21128045892014 @default.
• W2112804589 countsByYear W21128045892015 @default.
• W2112804589 countsByYear W21128045892017 @default.
• W2112804589 countsByYear W21128045892018 @default.
• W2112804589 countsByYear W21128045892020 @default.
• W2112804589 countsByYear W21128045892023 @default.
• W2112804589 crossrefType "journal-article" @default.
• W2112804589 hasAuthorship W2112804589A5002274261 @default.
• W2112804589 hasAuthorship W2112804589A5022252180 @default.
• W2112804589 hasAuthorship W2112804589A5035746727 @default.
• W2112804589 hasAuthorship W2112804589A5036575223 @default.
• W2112804589 hasAuthorship W2112804589A5047611204 @default.
• W2112804589 hasAuthorship W2112804589A5061617494 @default.
• W2112804589 hasAuthorship W2112804589A5062800007 @default.
• W2112804589 hasConcept C134018914 @default.
• W2112804589 hasConcept C153911025 @default.
• W2112804589 hasConcept C170493617 @default.
• W2112804589 hasConcept C17991360 @default.
• W2112804589 hasConcept C185592680 @default.
• W2112804589 hasConcept C187345961 @default.
• W2112804589 hasConcept C190283241 @default.
• W2112804589 hasConcept C2777542381 @default.
• W2112804589 hasConcept C2777622882 @default.
• W2112804589 hasConcept C519581460 @default.
• W2112804589 hasConcept C529278444 @default.
• W2112804589 hasConcept C55493867 @default.
• W2112804589 hasConcept C86803240 @default.
• W2112804589 hasConcept C95444343 @default.
• W2112804589 hasConceptScore W2112804589C134018914 @default.
• W2112804589 hasConceptScore W2112804589C153911025 @default.
• W2112804589 hasConceptScore W2112804589C170493617 @default.
• W2112804589 hasConceptScore W2112804589C17991360 @default.
• W2112804589 hasConceptScore W2112804589C185592680 @default.
• W2112804589 hasConceptScore W2112804589C187345961 @default.
• W2112804589 hasConceptScore W2112804589C190283241 @default.
• W2112804589 hasConceptScore W2112804589C2777542381 @default.

• next