Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112804922> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2112804922 endingPage "982" @default.
- W2112804922 startingPage "973" @default.
- W2112804922 abstract "The ability of MHC class II molecules to sort into the endocytic pathway has generally been attributed to the invariant chain glycoprotein. In this paper, we present evidence suggesting that lumenal sequences in the MHC class II molecule itself control the post-Golgi entry of class II into endosomes. Single amino acid changes have been introduced into a highly conserved region of the class II beta chain (amino acids 80-83). Mutant class II beta chain genes and wild-type alpha chain genes have been transfected into cells that lack both class II and invariant chain expression. Immunofluorescent staining of transfected cells indicates that single amino acid changes in this region of beta can positively or negatively modulate expression of class II in endocytic vesicles independently of invariant chain. Mutation at residue 80 leads to prominent localization in vesicular structures typical of late endocytic compartments, while a change at position 82 leads to arrest in the Golgi. These data argue in favor of the possibility that MHC class II molecules bear a sorting signal that allows access to MHC class II molecules into the endocytic pathway of antigen presenting cells." @default.
- W2112804922 created "2016-06-24" @default.
- W2112804922 creator A5009816649 @default.
- W2112804922 creator A5022795978 @default.
- W2112804922 creator A5074802230 @default.
- W2112804922 date "1994-01-01" @default.
- W2112804922 modified "2023-09-23" @default.
- W2112804922 title "A segment of the MHC class II β chain plays a critical role in targeting class II molecules to the endocytic pathway" @default.
- W2112804922 doi "https://doi.org/10.1093/intimm/6.7.973" @default.
- W2112804922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7947465" @default.
- W2112804922 hasPublicationYear "1994" @default.
- W2112804922 type Work @default.
- W2112804922 sameAs 2112804922 @default.
- W2112804922 citedByCount "48" @default.
- W2112804922 countsByYear W21128049222012 @default.
- W2112804922 countsByYear W21128049222014 @default.
- W2112804922 countsByYear W21128049222015 @default.
- W2112804922 crossrefType "journal-article" @default.
- W2112804922 hasAuthorship W2112804922A5009816649 @default.
- W2112804922 hasAuthorship W2112804922A5022795978 @default.
- W2112804922 hasAuthorship W2112804922A5074802230 @default.
- W2112804922 hasConcept C102747710 @default.
- W2112804922 hasConcept C119062480 @default.
- W2112804922 hasConcept C119997001 @default.
- W2112804922 hasConcept C147483822 @default.
- W2112804922 hasConcept C1491633281 @default.
- W2112804922 hasConcept C153911025 @default.
- W2112804922 hasConcept C158617107 @default.
- W2112804922 hasConcept C170627219 @default.
- W2112804922 hasConcept C185592680 @default.
- W2112804922 hasConcept C207936829 @default.
- W2112804922 hasConcept C2778814158 @default.
- W2112804922 hasConcept C28005876 @default.
- W2112804922 hasConcept C54355233 @default.
- W2112804922 hasConcept C55493867 @default.
- W2112804922 hasConcept C79747257 @default.
- W2112804922 hasConcept C79879829 @default.
- W2112804922 hasConcept C86803240 @default.
- W2112804922 hasConcept C95444343 @default.
- W2112804922 hasConceptScore W2112804922C102747710 @default.
- W2112804922 hasConceptScore W2112804922C119062480 @default.
- W2112804922 hasConceptScore W2112804922C119997001 @default.
- W2112804922 hasConceptScore W2112804922C147483822 @default.
- W2112804922 hasConceptScore W2112804922C1491633281 @default.
- W2112804922 hasConceptScore W2112804922C153911025 @default.
- W2112804922 hasConceptScore W2112804922C158617107 @default.
- W2112804922 hasConceptScore W2112804922C170627219 @default.
- W2112804922 hasConceptScore W2112804922C185592680 @default.
- W2112804922 hasConceptScore W2112804922C207936829 @default.
- W2112804922 hasConceptScore W2112804922C2778814158 @default.
- W2112804922 hasConceptScore W2112804922C28005876 @default.
- W2112804922 hasConceptScore W2112804922C54355233 @default.
- W2112804922 hasConceptScore W2112804922C55493867 @default.
- W2112804922 hasConceptScore W2112804922C79747257 @default.
- W2112804922 hasConceptScore W2112804922C79879829 @default.
- W2112804922 hasConceptScore W2112804922C86803240 @default.
- W2112804922 hasConceptScore W2112804922C95444343 @default.
- W2112804922 hasIssue "7" @default.
- W2112804922 hasLocation W21128049221 @default.
- W2112804922 hasLocation W21128049222 @default.
- W2112804922 hasOpenAccess W2112804922 @default.
- W2112804922 hasPrimaryLocation W21128049221 @default.
- W2112804922 hasRelatedWork W1977631515 @default.
- W2112804922 hasRelatedWork W1992945910 @default.
- W2112804922 hasRelatedWork W1998434423 @default.
- W2112804922 hasRelatedWork W2033821010 @default.
- W2112804922 hasRelatedWork W2094555935 @default.
- W2112804922 hasRelatedWork W2112804922 @default.
- W2112804922 hasRelatedWork W2125841216 @default.
- W2112804922 hasRelatedWork W2132466479 @default.
- W2112804922 hasRelatedWork W2553890461 @default.
- W2112804922 hasRelatedWork W2185435463 @default.
- W2112804922 hasVolume "6" @default.
- W2112804922 isParatext "false" @default.
- W2112804922 isRetracted "false" @default.
- W2112804922 magId "2112804922" @default.
- W2112804922 workType "article" @default.