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- W2112810653 abstract "Several experimental strategies of radiation-induced central nervous system toxicity prevention have recently resulted in encouraging data. The present review summarizes the background for this research and the treatment results. It extends to the perspectives of tissue regeneration strategies, based for example on stem and progenitor cells. Preliminary data suggest a scenario with individually tailored strategies where patients with certain types of comorbidity, resulting in impaired regeneration reserve capacity, might be considered for toxicity prevention, while others might be salvaged by delayed interventions that circumvent the problem of normal tissue specificity. Given the complexity of radiation-induced changes, single target interventions might not suffice. Future interventions might vary with patient age, elapsed time from radiotherapy and toxicity type. Potential components include several drugs that interact with neurodegeneration, cell transplantation (into the CNS itself, the blood stream, or both) and creation of reparative signals and a permissive microenvironment, e.g., for cell homing. Without manipulation of the stem cell niche either by cell transfection or addition of appropriate chemokines and growth factors and by providing normal perfusion of the affected region, durable success of such cell-based approaches is hard to imagine." @default.
- W2112810653 created "2016-06-24" @default.
- W2112810653 creator A5010504385 @default.
- W2112810653 creator A5044089012 @default.
- W2112810653 creator A5055289994 @default.
- W2112810653 date "2007-12-01" @default.
- W2112810653 modified "2023-09-28" @default.
- W2112810653 title "Experimental concepts for toxicity prevention and tissue restoration after central nervous system irradiation" @default.
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