FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112833180> ?p ?o ?g. }

• W2112833180 endingPage "576" @default.
• W2112833180 startingPage "563" @default.
• W2112833180 abstract "The chirality that is inherent in the enzyme systems of living organisms results in an abundance of enantiopure organic molecules in the living world. In addition to the optical properties first noticed by Pasteur, stereospecific interactions at recognition sites result in differences in both biological and toxicological effects. This fact underlies the continuing growth in chiral chemistry, rooted as it is in fundamental biochemistry. The pharmaceutical industry has undergone a strategic shift and embraced the wide spectrum of asymmetrical synthetic methods now available. The use of these processes in developmental synthesis and large-scale manufacturing has provided new challenges in drug discovery, motivated by a desire to improve industrial efficacy and decrease the time from the conception of a new drug to the market. The economic impact of the industrial production of chiral drugs is now huge--more than 50% of the 500 top-selling drugs were single-enantiomers in 1997. Sales have continued to increase by more than 20% for the past 6 yr and worldwide annual sales of enantiomeric drugs exceeded US$100 billion for the first time in the year 2000, chiral drugs representing close to one-third of all sales worldwide. While some 'chiral switches' may be of less apparent benefit, or indeed detrimental in some cases, encouragement by the regulatory agencies and the ability to extend the life cycle of a drug coming off patent promotes the trend. However, it may turn out to be the ability to provide chiral templates, and thereby attack the key targets of selectivity and specificity, that will lead to the greatest benefits. Research into new chemical entities that can interact specifically with enzyme families may potentially lead to new therapies for complex disease processes. As Richards has stated, the approach is designed to create a made to measure product, rather than one off the peg." @default.
• W2112833180 created "2016-06-24" @default.
• W2112833180 creator A5044038717 @default.
• W2112833180 creator A5066337213 @default.
• W2112833180 date "2002-04-01" @default.
• W2112833180 modified "2023-10-14" @default.
• W2112833180 title "Chirality: a blueprint for the future" @default.
• W2112833180 cites W1503588437 @default.
• W2112833180 cites W1599109036 @default.
• W2112833180 cites W1668093331 @default.
• W2112833180 cites W178389844 @default.
• W2112833180 cites W1964392630 @default.
• W2112833180 cites W1976504313 @default.
• W2112833180 cites W1990155291 @default.
• W2112833180 cites W1991095063 @default.
• W2112833180 cites W1991525120 @default.
• W2112833180 cites W1993545888 @default.
• W2112833180 cites W2000641039 @default.
• W2112833180 cites W2006231633 @default.
• W2112833180 cites W2012005596 @default.
• W2112833180 cites W2012452565 @default.
• W2112833180 cites W2012868014 @default.
• W2112833180 cites W2013985620 @default.
• W2112833180 cites W2014712933 @default.
• W2112833180 cites W2017824389 @default.
• W2112833180 cites W2017911662 @default.
• W2112833180 cites W2018912249 @default.
• W2112833180 cites W2019378606 @default.
• W2112833180 cites W2021818277 @default.
• W2112833180 cites W2022138769 @default.
• W2112833180 cites W2023196987 @default.
• W2112833180 cites W2033017054 @default.
• W2112833180 cites W2039115709 @default.
• W2112833180 cites W2039728759 @default.
• W2112833180 cites W2041322579 @default.
• W2112833180 cites W2041347922 @default.
• W2112833180 cites W2048644440 @default.
• W2112833180 cites W2053692594 @default.
• W2112833180 cites W2057580548 @default.
• W2112833180 cites W2060870413 @default.
• W2112833180 cites W2066609138 @default.
• W2112833180 cites W2073015466 @default.
• W2112833180 cites W2078098101 @default.
• W2112833180 cites W2078868792 @default.
• W2112833180 cites W2081108885 @default.
• W2112833180 cites W2083587900 @default.
• W2112833180 cites W2089004713 @default.
• W2112833180 cites W2089661078 @default.
• W2112833180 cites W2092157011 @default.
• W2112833180 cites W2093764922 @default.
• W2112833180 cites W2098960917 @default.
• W2112833180 cites W2099606274 @default.
• W2112833180 cites W2102110064 @default.
• W2112833180 cites W2120101425 @default.
• W2112833180 cites W2136037216 @default.
• W2112833180 cites W2157694088 @default.
• W2112833180 cites W2168663923 @default.
• W2112833180 cites W2168964406 @default.
• W2112833180 cites W2169938969 @default.
• W2112833180 cites W2171245354 @default.
• W2112833180 cites W2405738831 @default.
• W2112833180 cites W30895175 @default.
• W2112833180 cites W3191506763 @default.
• W2112833180 cites W4230532787 @default.
• W2112833180 cites W4234436622 @default.
• W2112833180 cites W4240252333 @default.
• W2112833180 cites W4243094305 @default.
• W2112833180 cites W4243442125 @default.
• W2112833180 cites W4243768129 @default.
• W2112833180 cites W4245588690 @default.
• W2112833180 cites W4247665721 @default.
• W2112833180 doi "https://doi.org/10.1093/bja/88.4.563" @default.
• W2112833180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12066734" @default.
• W2112833180 hasPublicationYear "2002" @default.
• W2112833180 type Work @default.
• W2112833180 sameAs 2112833180 @default.
• W2112833180 citedByCount "91" @default.
• W2112833180 countsByYear W21128331802012 @default.
• W2112833180 countsByYear W21128331802013 @default.
• W2112833180 countsByYear W21128331802014 @default.
• W2112833180 countsByYear W21128331802016 @default.
• W2112833180 countsByYear W21128331802017 @default.
• W2112833180 countsByYear W21128331802018 @default.
• W2112833180 countsByYear W21128331802019 @default.
• W2112833180 countsByYear W21128331802020 @default.
• W2112833180 countsByYear W21128331802021 @default.
• W2112833180 countsByYear W21128331802022 @default.
• W2112833180 crossrefType "journal-article" @default.
• W2112833180 hasAuthorship W2112833180A5044038717 @default.
• W2112833180 hasAuthorship W2112833180A5066337213 @default.
• W2112833180 hasBestOaLocation W21128331801 @default.
• W2112833180 hasConcept C121332964 @default.
• W2112833180 hasConcept C124668440 @default.
• W2112833180 hasConcept C127413603 @default.
• W2112833180 hasConcept C144133560 @default.
• W2112833180 hasConcept C146686406 @default.
• W2112833180 hasConcept C155911762 @default.
• W2112833180 hasConcept C161790260 @default.

• next