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- W2112842310 abstract "The heterohexameric minichromosome maintenance protein complex (Mcm2-7) functions as the eukaryotic helicase during DNA replication. Mcm2-7 loads onto chromatin during early G1 phase but is not converted into an active helicase until much later during S phase. Hence, inactive Mcm complexes are presumed to remain stably bound from early G1 through the completion of S phase. Here, we investigated Mcm protein dynamics in live mammalian cells. We demonstrate that Mcm proteins are irreversibly loaded onto chromatin cumulatively throughout G1 phase, showing no detectable exchange with a gradually diminishing soluble pool. Eviction of Mcm requires replication; during replication arrest, Mcm proteins remained bound indefinitely. Moreover, the density of immobile Mcms is reduced together with chromatin decondensation within sites of active replication, which provides an explanation for the lack of colocalization of Mcm with replication fork proteins. These results provide in vivo evidence for an exceptionally stable lockdown mechanism to retain all loaded Mcm proteins on chromatin throughout prolonged cell cycles." @default.
- W2112842310 created "2016-06-24" @default.
- W2112842310 creator A5020541064 @default.
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- W2112842310 creator A5084561710 @default.
- W2112842310 date "2011-01-10" @default.
- W2112842310 modified "2023-09-26" @default.
- W2112842310 title "Highly stable loading of Mcm proteins onto chromatin in living cells requires replication to unload" @default.
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- W2112842310 doi "https://doi.org/10.1083/jcb.201007111" @default.
- W2112842310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3019549" @default.
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- W2112842310 hasPublicationYear "2011" @default.
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