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• W2112852213 abstract "anti-Substituted biaryl β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors that suffer from suboptimal selectivity and pharmacokinetics. This letter describes the substitution of the β-methyl substituent with β-polar substituents, culminating in the discovery of a β-dimethylamide substituted phenylalanine derivative with an excellent potency, selectivity, and pharmacokinetic profile." @default.
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• W2112852213 date "2005-06-01" @default.
• W2112852213 modified "2023-10-03" @default.
• W2112852213 title "Discovery of potent and selective orally bioavailable β-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors" @default.
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• W2112852213 doi "https://doi.org/10.1016/j.bmcl.2005.04.028" @default.
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