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- W2112862472 abstract "This study evaluated immunomodulatory properties and the sub-acute toxicity profile of two fractions of the aqueous alcoholic extract of the dried calyx of Hibiscus sabdariffa in experimental animals. Immunomodulatory activity was evaluated using red blood cell-induced immunostimulation. The fractions were not found to be toxic after 7-day administration, though there was severe weight loss with the residual water-soluble fraction (RWSF) and weight gain with the ethyl acetate soluble fraction (EAC). The EAC exhibited a significant dose-dependent immunostimulation (p<0.05) higher than that observed for levamisole (positive control). The residual water-soluble fraction exhibited immunostimulatory activity at 100 mg/kg body weight. The two fractions caused a significant reduction in production of tissue necrosis factor-alpha and an increase in interleukin 10 (IL-10)." @default.
- W2112862472 created "2016-06-24" @default.
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- W2112862472 date "2008-06-18" @default.
- W2112862472 modified "2023-09-23" @default.
- W2112862472 title "Toxicity and immunomodulatory activity of fractions of Hibiscus sabdariffa Linn (family Malvaceae) in animal models." @default.
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