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• W2112879454 abstract "We previously reported that if murine leukemia virus particles are produced in the presence of the mild oxidizing agent disulfide-substituted benzamide-2, they fail to undergo the normal process of virus maturation. We now show that treatment of these immature particles with a reducing agent (dithiothreitol) induces their maturation in vitro, as evidenced by proteolytic cleavage of Gag, Gag-Pol, and Env proteins and by their morphology. The identification of partial cleavage products in these particles suggests the sequence with which the cleavages occur under these conditions. This may be a useful experimental system for further analysis of retroviral maturation under controlled conditions in vitro." @default.
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• W2112879454 date "2002-10-01" @default.
• W2112879454 modified "2023-10-16" @default.
• W2112879454 title "Reversal by Dithiothreitol Treatment of the Block in Murine Leukemia Virus Maturation Induced by Disulfide Cross-Linking" @default.
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• W2112879454 doi "https://doi.org/10.1128/jvi.76.19.10050-10055.2002" @default.
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