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• W2112901290 abstract "Small noncoding regulatory RNAs (sRNAs) play a key role in regulating the expression of many genes in Escherichia coli and other bacteria. Many of the sRNAs identified in E. coli bind to mRNAs in an Hfq-dependent manner and stimulate or inhibit translation of the mRNAs. Several sRNAs are regulated by well-studied global regulators. Here, we report characterization of the CyaR (RyeE) sRNA, which was previously identified in a global search for sRNAs in E. coli. We demonstrated that CyaR is positively regulated by the global regulator Crp under conditions in which cyclic AMP levels are high. We showed by using microarray analysis and Northern blotting that several genes are negatively regulated by CyaR, including ompX, encoding a major outer membrane protein; luxS, encoding the autoinducer-2 synthase; nadE, encoding an essential NAD synthetase; and yqaE, encoding a predicted membrane protein with an unknown function. Using translational lacZ fusions to yqaE, ompX, nadE, and luxS, we demonstrated that the negative regulation of these genes by CyaR occurs at the posttranscriptional level and is direct. Different portions of a highly conserved 3' region of CyaR are predicted to pair with sequences near the ribosome binding site of each of these targets; mutations in this sequence affected regulation, and compensatory mutations in the target mRNA restored regulation, confirming that there is direct regulation by the sRNA. These results provide insight into the mechanisms by which Crp negatively regulates genes such as luxS and ompX and provide a link between catabolite repression, quorum sensing, and nitrogen assimilation in E. coli." @default.
• W2112901290 created "2016-06-24" @default.
• W2112901290 creator A5072809760 @default.
• W2112901290 creator A5076610811 @default.
• W2112901290 date "2009-01-15" @default.
• W2112901290 modified "2023-10-15" @default.
• W2112901290 title "The Crp-Activated Small Noncoding Regulatory RNA CyaR (RyeE) Links Nutritional Status to Group Behavior" @default.
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• W2112901290 doi "https://doi.org/10.1128/jb.01157-08" @default.
• W2112901290 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2620814" @default.
• W2112901290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18978044" @default.
• W2112901290 hasPublicationYear "2009" @default.
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