FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112910561> ?p ?o ?g. }

• W2112910561 endingPage "1452" @default.
• W2112910561 startingPage "1441" @default.
• W2112910561 abstract "Activation-induced cell death in macrophages has been observed, but the mechanism remains largely unknown. Activation-induced cell death in macrophages can be independent from caspases, and the death of activated macrophages can even be triggered by the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD). Here, we show that this type of macrophage death can occur in the septic mouse model and that toll-like receptor (TLR)-2 or TLR4 signaling is required in this process. We conclude that Nur77 is involved in the macrophage death because Nur77 expression correlates with cell death, and cell death is reduced significantly in Nur77-deficient macrophages. The extracellular signal-regulated kinase pathway, which is downstream of TLR2 or TLR4, and myocyte-specific enhancer binding factor 2 (MEF2) transcription factor activity, which is up-regulated by zVAD, are required for Nur77 induction and macrophage death. Reporter gene analysis suggests that Nap, Ets, Rce, and Sp1 sites in the Nur77 promoter are regulated by TLR4 signaling and that MEF2 sites in the Nur77 promoter are regulated by zVAD treatment. MEF2 transcription factors are constitutively expressed and degraded in macrophages, and zVAD increases MEF2 transcription factor activity by preventing the proteolytic cleavage and degradation of MEF2 proteins. This paper delineates the dual signaling pathways that are required for Nur77 induction in macrophages and demonstrates a role of Nur77 in caspase-independent cell death." @default.
• W2112910561 created "2016-06-24" @default.
• W2112910561 creator A5005311216 @default.
• W2112910561 creator A5037380925 @default.
• W2112910561 creator A5069188763 @default.
• W2112910561 creator A5087157245 @default.
• W2112910561 date "2003-06-02" @default.
• W2112910561 modified "2023-09-23" @default.
• W2112910561 title "Orphan Nuclear Receptor Nur77 Is Involved in Caspase-independent Macrophage Cell Death" @default.
• W2112910561 cites W1482815643 @default.
• W2112910561 cites W1499659307 @default.
• W2112910561 cites W1523845694 @default.
• W2112910561 cites W1553610971 @default.
• W2112910561 cites W1584961069 @default.
• W2112910561 cites W1602075904 @default.
• W2112910561 cites W1650631631 @default.
• W2112910561 cites W1873493101 @default.
• W2112910561 cites W1946206391 @default.
• W2112910561 cites W1969543607 @default.
• W2112910561 cites W1975672275 @default.
• W2112910561 cites W1980655244 @default.
• W2112910561 cites W1984695968 @default.
• W2112910561 cites W1992263554 @default.
• W2112910561 cites W1993156906 @default.
• W2112910561 cites W1994449425 @default.
• W2112910561 cites W1997858052 @default.
• W2112910561 cites W2000252988 @default.
• W2112910561 cites W2008152503 @default.
• W2112910561 cites W2017493275 @default.
• W2112910561 cites W2028965789 @default.
• W2112910561 cites W2031578421 @default.
• W2112910561 cites W2036549033 @default.
• W2112910561 cites W2036989365 @default.
• W2112910561 cites W2040259670 @default.
• W2112910561 cites W2042409437 @default.
• W2112910561 cites W2057606579 @default.
• W2112910561 cites W2065123578 @default.
• W2112910561 cites W2065934473 @default.
• W2112910561 cites W2068883241 @default.
• W2112910561 cites W2077671923 @default.
• W2112910561 cites W2078850134 @default.
• W2112910561 cites W2089751234 @default.
• W2112910561 cites W2090774694 @default.
• W2112910561 cites W2093455126 @default.
• W2112910561 cites W2094701037 @default.
• W2112910561 cites W2107907376 @default.
• W2112910561 cites W2110530182 @default.
• W2112910561 cites W2125836447 @default.
• W2112910561 cites W2126142493 @default.
• W2112910561 cites W2129041175 @default.
• W2112910561 cites W2131849622 @default.
• W2112910561 cites W2146453887 @default.
• W2112910561 cites W2148666139 @default.
• W2112910561 cites W2149811610 @default.
• W2112910561 cites W2153442943 @default.
• W2112910561 cites W2154122218 @default.
• W2112910561 cites W2157549025 @default.
• W2112910561 cites W2159069239 @default.
• W2112910561 cites W2161996856 @default.
• W2112910561 cites W2168335590 @default.
• W2112910561 cites W2171729220 @default.
• W2112910561 cites W2377936835 @default.
• W2112910561 cites W2443343209 @default.
• W2112910561 cites W40001950 @default.
• W2112910561 cites W4255843906 @default.
• W2112910561 doi "https://doi.org/10.1084/jem.20021842" @default.
• W2112910561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193909" @default.
• W2112910561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12782711" @default.
• W2112910561 hasPublicationYear "2003" @default.
• W2112910561 type Work @default.
• W2112910561 sameAs 2112910561 @default.
• W2112910561 citedByCount "82" @default.
• W2112910561 countsByYear W21129105612012 @default.
• W2112910561 countsByYear W21129105612013 @default.
• W2112910561 countsByYear W21129105612014 @default.
• W2112910561 countsByYear W21129105612015 @default.
• W2112910561 countsByYear W21129105612016 @default.
• W2112910561 countsByYear W21129105612017 @default.
• W2112910561 countsByYear W21129105612018 @default.
• W2112910561 countsByYear W21129105612019 @default.
• W2112910561 countsByYear W21129105612020 @default.
• W2112910561 countsByYear W21129105612021 @default.
• W2112910561 countsByYear W21129105612022 @default.
• W2112910561 countsByYear W21129105612023 @default.
• W2112910561 crossrefType "journal-article" @default.
• W2112910561 hasAuthorship W2112910561A5005311216 @default.
• W2112910561 hasAuthorship W2112910561A5037380925 @default.
• W2112910561 hasAuthorship W2112910561A5069188763 @default.
• W2112910561 hasAuthorship W2112910561A5087157245 @default.
• W2112910561 hasBestOaLocation W21129105611 @default.
• W2112910561 hasConcept C104317684 @default.
• W2112910561 hasConcept C111936080 @default.
• W2112910561 hasConcept C153911025 @default.
• W2112910561 hasConcept C190283241 @default.
• W2112910561 hasConcept C31573885 @default.
• W2112910561 hasConcept C35552991 @default.
• W2112910561 hasConcept C48297814 @default.
• W2112910561 hasConcept C502942594 @default.

• next