Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112912134> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2112912134 endingPage "772" @default.
- W2112912134 startingPage "765" @default.
- W2112912134 abstract "β-Adrenoceptor antagonists have been employed as first-line therapy for reducing elevated intraocular pressure for many years. Recently, and almost simultaneously, three new classes of drugs have been clinically evaluated for treating glaucoma. These are topically-effective carbonic anhydrase (CA) inhibitors, ′2-adrenoceptor agonists, and prostaglandin F2′ analogues. Members of each of these groups have been granted approval by regulatory agencies. CA inhibitors and ′2-adrenoceptor agonists, like β-adrenoceptor antagonists, reduce intraocular pressure by suppressing aqueous humour secretion. Despite the exceptional in vitro potency of dorzolamide in inhibiting human CA II, and physicochemical properties that confer good ocular bioavailability, direct comparison indicates that even this compound is less efficacious than the β-blocker timolol. Since the invention of dorzolamide is widely regarded as a monumental scientific achievement, it does not seem likely that a better CA inhibitor will become available in clinical practice. In contrast, there appears to be scope for improving on the ′2-adrenoceptor agonist apraclonidine, which has now been approved for glaucoma but with some significant restrictions. Brimonidine may be regarded as a second-generation ′2-adrenoceptor agonist that has an improved safety profile and well-maintained efficacy. Future knowledge gained with respect to ocular ′2-adrenoceptor and imidazoline receptor subtype distribution and function could provide yet further improvements.Prostaglandins are unique in two important respects. They appear to be more efficacious than β-blockers and possess a unique mechanism of action that involves increasing aqueous humour drainage from the eye rather than inhibition of aqueous humour secretion. All indications suggest that prostanoids represent the next real advance in glaucoma therapy." @default.
- W2112912134 created "2016-06-24" @default.
- W2112912134 creator A5091203059 @default.
- W2112912134 date "1996-08-01" @default.
- W2112912134 modified "2023-09-27" @default.
- W2112912134 title "Section Review Cardiovascular & Renal: Glaucoma: Novel agents and recent therapeutic advances" @default.
- W2112912134 cites W1970730203 @default.
- W2112912134 cites W1985838582 @default.
- W2112912134 cites W1990333822 @default.
- W2112912134 cites W1990487896 @default.
- W2112912134 cites W1992693589 @default.
- W2112912134 cites W1995114469 @default.
- W2112912134 cites W2016735163 @default.
- W2112912134 cites W2022264363 @default.
- W2112912134 cites W2034485627 @default.
- W2112912134 cites W2044820440 @default.
- W2112912134 cites W2048014260 @default.
- W2112912134 cites W2061876592 @default.
- W2112912134 cites W2070500919 @default.
- W2112912134 cites W2092659719 @default.
- W2112912134 cites W2167193438 @default.
- W2112912134 cites W2175261879 @default.
- W2112912134 doi "https://doi.org/10.1517/13543776.6.8.765" @default.
- W2112912134 hasPublicationYear "1996" @default.
- W2112912134 type Work @default.
- W2112912134 sameAs 2112912134 @default.
- W2112912134 citedByCount "2" @default.
- W2112912134 crossrefType "journal-article" @default.
- W2112912134 hasAuthorship W2112912134A5091203059 @default.
- W2112912134 hasConcept C118487528 @default.
- W2112912134 hasConcept C126322002 @default.
- W2112912134 hasConcept C170493617 @default.
- W2112912134 hasConcept C181199279 @default.
- W2112912134 hasConcept C185592680 @default.
- W2112912134 hasConcept C2775914622 @default.
- W2112912134 hasConcept C2776727336 @default.
- W2112912134 hasConcept C2778073030 @default.
- W2112912134 hasConcept C2778076468 @default.
- W2112912134 hasConcept C2778190193 @default.
- W2112912134 hasConcept C2778527774 @default.
- W2112912134 hasConcept C2778938600 @default.
- W2112912134 hasConcept C2779984381 @default.
- W2112912134 hasConcept C2781092963 @default.
- W2112912134 hasConcept C55493867 @default.
- W2112912134 hasConcept C71924100 @default.
- W2112912134 hasConcept C98274493 @default.
- W2112912134 hasConceptScore W2112912134C118487528 @default.
- W2112912134 hasConceptScore W2112912134C126322002 @default.
- W2112912134 hasConceptScore W2112912134C170493617 @default.
- W2112912134 hasConceptScore W2112912134C181199279 @default.
- W2112912134 hasConceptScore W2112912134C185592680 @default.
- W2112912134 hasConceptScore W2112912134C2775914622 @default.
- W2112912134 hasConceptScore W2112912134C2776727336 @default.
- W2112912134 hasConceptScore W2112912134C2778073030 @default.
- W2112912134 hasConceptScore W2112912134C2778076468 @default.
- W2112912134 hasConceptScore W2112912134C2778190193 @default.
- W2112912134 hasConceptScore W2112912134C2778527774 @default.
- W2112912134 hasConceptScore W2112912134C2778938600 @default.
- W2112912134 hasConceptScore W2112912134C2779984381 @default.
- W2112912134 hasConceptScore W2112912134C2781092963 @default.
- W2112912134 hasConceptScore W2112912134C55493867 @default.
- W2112912134 hasConceptScore W2112912134C71924100 @default.
- W2112912134 hasConceptScore W2112912134C98274493 @default.
- W2112912134 hasIssue "8" @default.
- W2112912134 hasLocation W21129121341 @default.
- W2112912134 hasOpenAccess W2112912134 @default.
- W2112912134 hasPrimaryLocation W21129121341 @default.
- W2112912134 hasRelatedWork W1966515878 @default.
- W2112912134 hasRelatedWork W2014785256 @default.
- W2112912134 hasRelatedWork W2027345384 @default.
- W2112912134 hasRelatedWork W2137843852 @default.
- W2112912134 hasRelatedWork W2324003810 @default.
- W2112912134 hasRelatedWork W2612340917 @default.
- W2112912134 hasRelatedWork W3138731514 @default.
- W2112912134 hasRelatedWork W4236194397 @default.
- W2112912134 hasRelatedWork W4245793165 @default.
- W2112912134 hasRelatedWork W4296007681 @default.
- W2112912134 hasVolume "6" @default.
- W2112912134 isParatext "false" @default.
- W2112912134 isRetracted "false" @default.
- W2112912134 magId "2112912134" @default.
- W2112912134 workType "article" @default.