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• W2112927741 abstract "// Muhammad Ary Zucha 1,2 , Alexander T.H. Wu 3,4 , Wei-Hwa Lee 5 , Liang-Shun Wang 6 , Wan-Wan Lin 1 , Chiou-Chung Yuan 7 , Chi-Tai Yeh 6,8 1 Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan 2 Department of Obstetrics and Gynecology, Gadjah Mada University-Sardjito Central Hospital, Yogyakarta, Indonesia 3 Graduate Institute of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan 4 Translational Research Laboratory, Cancer Center, Taipei Medical University Hospital, Taipei, Taiwan 5 Department of Pathology, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan 6 Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan 7 Obstetrics and Gynecology Department, Shuang-Ho Hospital, Taipei, Taiwan 8 Department of Medical Research and Education, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan Correspondence to: Chi-Tai Yeh, email: // Chiou-Chung Yuan, email: // Keywords : ovarian cancer, cancer stem cell (CSC), spheroids, ibrutinib, Bruton’s tyrosine kinase (Btk), cisplatin Received : December 14, 2014 Accepted : February 28, 2015 Published : March 26, 2015 Abstract According to a Prognoscan database, upregulation of Bruton’s tyrosine kinase (Btk) is associated with low overall survival in ovarian cancer patients. We found that spheroids-forming ovarian cancer cell, which highly expressed cancer stem-like cell (CSC) markers and Btk, were cisplatin resistant. We next treated CSCs and non-CSCs by a combination of ibrutinib and cisplatin. We found that chemoresistance was dependent on Btk and JAK2/STAT3, which maintained CSC by inducing Sox-2 and prosurvival genes. We suggest that addition of ibrutinib to cisplatin may improve treatment outcome in ovarian cancer." @default.
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• W2112927741 date "2015-03-26" @default.
• W2112927741 modified "2023-10-17" @default.
• W2112927741 title "Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer" @default.
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• W2112927741 doi "https://doi.org/10.18632/oncotarget.3658" @default.
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