FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112974611> ?p ?o ?g. }

• W2112974611 endingPage "733" @default.
• W2112974611 startingPage "724" @default.
• W2112974611 abstract "The differential contribution of the virulence factors invasin, protein tyrosine phosphatase (YopH), cytotoxin (YopE), and adhesin (YadA) of Yersinia enterocolitica to evasion of the antibacterial activities of polymorphonuclear leukocytes (PMNs) (oxidative burst, phagocytosis, killing) was analyzed. We constructed virulence gene knockout mutants and a novel two-plasmid system allowing production and secretion of individual virulence factors. Wild-type Y. enterocolitica WA-314 harboring the virulence plasmid pYV08 resisted phagocytosis and killing by PMNs. Moreover, strain WA-314 was able to inhibit the neutrophil oxidative burst upon stimulation with opsonized zymosan independently on preincubation with normal human serum or YadA-specific serum. These phenotypic properties of strain WA-314 were differentially affected when mutants impaired in YadA production or Yop secretion were used. A more detailed analysis revealed that YopH plays the dominant role in suppression of the antibacterial action of PMNs without damaging the cells. The YopH suppressing effect could be enhanced by coproduction of YopE and YadA. The contribution of YadA is attributed to the adhesin function promoting interaction with PMNs under both opsonizing and nonopsonizing conditions. In contrast, invasin seems to mediate only opsonin-independent interaction with PMNs. Taken together, our results demonstrate that YopH, YopE, and YadA act in concert towards neutrophil attack to enable extracellular survival of Y. enterocolitica in host tissue." @default.
• W2112974611 created "2016-06-24" @default.
• W2112974611 creator A5013191103 @default.
• W2112974611 creator A5013601902 @default.
• W2112974611 creator A5034745868 @default.
• W2112974611 creator A5061433515 @default.
• W2112974611 date "1996-03-01" @default.
• W2112974611 modified "2023-09-23" @default.
• W2112974611 title "Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils" @default.
• W2112974611 cites W158273916 @default.
• W2112974611 cites W1635093970 @default.
• W2112974611 cites W1763487877 @default.
• W2112974611 cites W1787690277 @default.
• W2112974611 cites W1856938772 @default.
• W2112974611 cites W1863690422 @default.
• W2112974611 cites W1896483236 @default.
• W2112974611 cites W1908152925 @default.
• W2112974611 cites W1910760362 @default.
• W2112974611 cites W1930066700 @default.
• W2112974611 cites W1937123239 @default.
• W2112974611 cites W1944680642 @default.
• W2112974611 cites W1945295317 @default.
• W2112974611 cites W1977380444 @default.
• W2112974611 cites W1979864900 @default.
• W2112974611 cites W1982005911 @default.
• W2112974611 cites W1982279026 @default.
• W2112974611 cites W1992019446 @default.
• W2112974611 cites W1997074046 @default.
• W2112974611 cites W2003052518 @default.
• W2112974611 cites W2005305957 @default.
• W2112974611 cites W2043627486 @default.
• W2112974611 cites W2044025320 @default.
• W2112974611 cites W2044684178 @default.
• W2112974611 cites W2046428666 @default.
• W2112974611 cites W2049071764 @default.
• W2112974611 cites W2049290302 @default.
• W2112974611 cites W2058933513 @default.
• W2112974611 cites W2059401988 @default.
• W2112974611 cites W2067420644 @default.
• W2112974611 cites W2092967278 @default.
• W2112974611 cites W2097430137 @default.
• W2112974611 cites W2097432675 @default.
• W2112974611 cites W2102770487 @default.
• W2112974611 cites W2112515643 @default.
• W2112974611 cites W2120838187 @default.
• W2112974611 cites W2124221462 @default.
• W2112974611 cites W2124788702 @default.
• W2112974611 cites W2127135538 @default.
• W2112974611 cites W2130941393 @default.
• W2112974611 cites W2131428539 @default.
• W2112974611 cites W2133496972 @default.
• W2112974611 cites W2147325008 @default.
• W2112974611 cites W2149177078 @default.
• W2112974611 cites W2149214122 @default.
• W2112974611 cites W2151041659 @default.
• W2112974611 cites W2177781499 @default.
• W2112974611 cites W2234738384 @default.
• W2112974611 cites W2319903483 @default.
• W2112974611 cites W2343892197 @default.
• W2112974611 cites W2416770620 @default.
• W2112974611 doi "https://doi.org/10.1128/iai.64.3.724-733.1996" @default.
• W2112974611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/173829" @default.
• W2112974611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8641773" @default.
• W2112974611 hasPublicationYear "1996" @default.
• W2112974611 type Work @default.
• W2112974611 sameAs 2112974611 @default.
• W2112974611 citedByCount "156" @default.
• W2112974611 countsByYear W21129746112012 @default.
• W2112974611 countsByYear W21129746112013 @default.
• W2112974611 countsByYear W21129746112014 @default.
• W2112974611 countsByYear W21129746112015 @default.
• W2112974611 countsByYear W21129746112016 @default.
• W2112974611 countsByYear W21129746112017 @default.
• W2112974611 countsByYear W21129746112019 @default.
• W2112974611 countsByYear W21129746112020 @default.
• W2112974611 countsByYear W21129746112022 @default.
• W2112974611 crossrefType "journal-article" @default.
• W2112974611 hasAuthorship W2112974611A5013191103 @default.
• W2112974611 hasAuthorship W2112974611A5013601902 @default.
• W2112974611 hasAuthorship W2112974611A5034745868 @default.
• W2112974611 hasAuthorship W2112974611A5061433515 @default.
• W2112974611 hasBestOaLocation W21129746111 @default.
• W2112974611 hasConcept C104317684 @default.
• W2112974611 hasConcept C160448771 @default.
• W2112974611 hasConcept C179470777 @default.
• W2112974611 hasConcept C2776234502 @default.
• W2112974611 hasConcept C2776255393 @default.
• W2112974611 hasConcept C39103817 @default.
• W2112974611 hasConcept C49039625 @default.
• W2112974611 hasConcept C523546767 @default.
• W2112974611 hasConcept C54355233 @default.
• W2112974611 hasConcept C55493867 @default.
• W2112974611 hasConcept C60987743 @default.
• W2112974611 hasConcept C86803240 @default.
• W2112974611 hasConcept C89372155 @default.
• W2112974611 hasConcept C89423630 @default.
• W2112974611 hasConceptScore W2112974611C104317684 @default.
• W2112974611 hasConceptScore W2112974611C160448771 @default.

• next