FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112984195> ?p ?o ?g. }

• W2112984195 endingPage "4088" @default.
• W2112984195 startingPage "4081" @default.
• W2112984195 abstract "ABSTRACT Temporal and spatial gene regulation during Bacillus subtilis sporulation involves the activation and inactivation of multiple sigma subunits of RNA polymerase in a cascade. In the mother cell compartment of sporulating cells, expression of the sigE gene, encoding the earlier-acting sigma factor, ς E , is negatively regulated by the later-acting sigma factor, ς K . Here, it is shown that the negative feedback loop does not require SinR, an inhibitor of sigE transcription. Production of ς K about 1 h earlier than normal does affect Spo0A, which when phosphorylated is an activator of sigE transcription. A mutation in the spo0A gene, which bypasses the phosphorelay leading to the phosphorylation of Spo0A, diminished the negative effect of early ς K production on sigE expression early in sporulation. Also, early production of ς K reduced expression of other Spo0A-dependent genes but not expression of the Spo0A-independent ald gene. In contrast, both sigE and ald were overexpressed late in development of cells that fail to make ς K . The ald promoter, like the sigE promoter, is believed to be recognized by ς A RNA polymerase, suggesting that ς K may inhibit ς A activity late in sporulation. To exert this negative effect, ς K must be transcriptionally active. A mutant form of ς K that associates with core RNA polymerase, but does not direct transcription of a ς K -dependent gene, failed to negatively regulate expression of sigE or ald late in development. On the other hand, the negative effect of early ς K production on sigE expression early in sporulation did not require transcriptional activity of ς K RNA polymerase. These results demonstrate that ς K can negatively regulate sigE expression by two different mechanisms, one observed when ς K is produced earlier than normal, which does not require ς K to be transcriptionally active and affects Spo0A, and the other observed when ς K is produced at the normal time, which requires ς K RNA polymerase transcriptional activity. The latter mechanism facilitates the switch from ς E to ς K in the cascade controlling mother cell gene expression." @default.
• W2112984195 created "2016-06-24" @default.
• W2112984195 creator A5003349803 @default.
• W2112984195 creator A5029058960 @default.
• W2112984195 creator A5048946642 @default.
• W2112984195 date "1999-07-01" @default.
• W2112984195 modified "2023-10-18" @default.
• W2112984195 title "ς K Can Negatively Regulate sigE Expression by Two Different Mechanisms during Sporulation of Bacillus subtilis" @default.
• W2112984195 cites W1490028929 @default.
• W2112984195 cites W1499595340 @default.
• W2112984195 cites W1529324281 @default.
• W2112984195 cites W1539601278 @default.
• W2112984195 cites W1558525371 @default.
• W2112984195 cites W1560298788 @default.
• W2112984195 cites W1571904247 @default.
• W2112984195 cites W1582834972 @default.
• W2112984195 cites W1599443638 @default.
• W2112984195 cites W1601063816 @default.
• W2112984195 cites W1605139332 @default.
• W2112984195 cites W1658229959 @default.
• W2112984195 cites W1718807327 @default.
• W2112984195 cites W1757147742 @default.
• W2112984195 cites W1784624442 @default.
• W2112984195 cites W1797965567 @default.
• W2112984195 cites W1831228939 @default.
• W2112984195 cites W1867480659 @default.
• W2112984195 cites W1931964389 @default.
• W2112984195 cites W1947574399 @default.
• W2112984195 cites W1964028235 @default.
• W2112984195 cites W1964295658 @default.
• W2112984195 cites W1965702106 @default.
• W2112984195 cites W1967025437 @default.
• W2112984195 cites W1969506266 @default.
• W2112984195 cites W1975505917 @default.
• W2112984195 cites W1976436203 @default.
• W2112984195 cites W1977967488 @default.
• W2112984195 cites W1985657539 @default.
• W2112984195 cites W1997774522 @default.
• W2112984195 cites W1997971408 @default.
• W2112984195 cites W2004571183 @default.
• W2112984195 cites W2020657021 @default.
• W2112984195 cites W2023737966 @default.
• W2112984195 cites W2026543895 @default.
• W2112984195 cites W2029491032 @default.
• W2112984195 cites W2030285233 @default.
• W2112984195 cites W2030911977 @default.
• W2112984195 cites W2032230508 @default.
• W2112984195 cites W2032328912 @default.
• W2112984195 cites W2032617910 @default.
• W2112984195 cites W2034159958 @default.
• W2112984195 cites W2044812677 @default.
• W2112984195 cites W2045050792 @default.
• W2112984195 cites W2053011400 @default.
• W2112984195 cites W2053149333 @default.
• W2112984195 cites W2072801128 @default.
• W2112984195 cites W2078321980 @default.
• W2112984195 cites W2082830529 @default.
• W2112984195 cites W2085686817 @default.
• W2112984195 cites W2089526387 @default.
• W2112984195 cites W2095955490 @default.
• W2112984195 cites W2095960226 @default.
• W2112984195 cites W2103677208 @default.
• W2112984195 cites W2106889107 @default.
• W2112984195 cites W2110635777 @default.
• W2112984195 cites W2115024759 @default.
• W2112984195 cites W2117923441 @default.
• W2112984195 cites W2123475271 @default.
• W2112984195 cites W2123720278 @default.
• W2112984195 cites W2132298226 @default.
• W2112984195 cites W2133133228 @default.
• W2112984195 cites W2134387717 @default.
• W2112984195 cites W2137377344 @default.
• W2112984195 cites W2138170124 @default.
• W2112984195 cites W2140324276 @default.
• W2112984195 cites W2150965136 @default.
• W2112984195 cites W2154225603 @default.
• W2112984195 cites W2158174364 @default.
• W2112984195 cites W2158318887 @default.
• W2112984195 cites W2159180021 @default.
• W2112984195 cites W2888511473 @default.
• W2112984195 doi "https://doi.org/10.1128/jb.181.13.4081-4088.1999" @default.
• W2112984195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/93900" @default.
• W2112984195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10383978" @default.
• W2112984195 hasPublicationYear "1999" @default.
• W2112984195 type Work @default.
• W2112984195 sameAs 2112984195 @default.
• W2112984195 citedByCount "27" @default.
• W2112984195 countsByYear W21129841952012 @default.
• W2112984195 countsByYear W21129841952014 @default.
• W2112984195 countsByYear W21129841952015 @default.
• W2112984195 countsByYear W21129841952016 @default.
• W2112984195 countsByYear W21129841952019 @default.
• W2112984195 countsByYear W21129841952020 @default.
• W2112984195 countsByYear W21129841952021 @default.
• W2112984195 crossrefType "journal-article" @default.
• W2112984195 hasAuthorship W2112984195A5003349803 @default.
• W2112984195 hasAuthorship W2112984195A5029058960 @default.
• W2112984195 hasAuthorship W2112984195A5048946642 @default.

• next