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- W2112996669 abstract "Abstract: In complex kinship cases, markers situated in haplotypic blocks may provide additional clues to other unlinked markers. We have established a protocol to amplify six X-chromosome microsatellites, located in two haplotype blocks, using PCR with fluorochrome-labeled primers and capillary electrophoresis. The segregation stability was explored in 92 unrelated families with individuals from three generations. Sixty-one different haplotypes were found in the DXS10079-DXS10074-DXS10075 block in the grandfathers and 96 in the mothers, with estimated haplotype diversities of 0.9828 and 0.9842, respectively. Fifty and 73 different haplotypes were found in the DXS6801-DXS6809-DXS6789 block in the grandfathers and the mothers, with estimated haplotype diversities of 0.9711 and 0.9742, respectively. We observed 10 between-cluster and one within-cluster recombinations in 99 female meioses. The overall per-locus mutation rate was 0.0034. This protocol allows for the characterization of the alleles of two sets of linked markers of the X-chromosome that can be useful in complex forensic cases." @default.
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- W2112996669 date "2011-09-16" @default.
- W2112996669 modified "2023-09-25" @default.
- W2112996669 title "Haplotypic Blocks of X-linked STRs for Forensic Cases: Study of Recombination and Mutation Rates*" @default.
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- W2112996669 doi "https://doi.org/10.1111/j.1556-4029.2011.01916.x" @default.
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